2.1 Study Approval
All procedures were approved by The Institutional Animals Ethics Committees at Henan University, Kaifeng, China under and the national guidelines under which the institution operates, and also conform with the NIH Guide for the Care and Use of Laboratory Animals. Guinea pigs (male; 300-350 g) were provided by The Experimental Animal Center of the Medical College of Xi’an Jiaotong University and maintained in a pathogen−free facility at Henan University with ad libitum access to food and water. Animals were humanely sacrificed by intraperitoneal injection with 3% pentobarbital sodium (50 mg/kg).