Sources of Funding

This work is supported by the Kaifeng Excellent Key Laboratory Grant (Grant no. 20190601A) British Heart Foundation (BHF) (PG/14/79/31102, and PG/15/12/31280 and BHF Centres for Research Excellence (CRE) at Cambridge, CLHH, PG/14/80/31106, PG/16/67/32340, ML, PG. FS/17/52/33113,AT) and Oxford (ML) the Chinese Natural Science Foundation (31171085: ML) and EPSRC (United Kingdom) (EP/J00958X/1 and EP/I029826/1) (HZ).

Disclosures

The authors have declared that no conflict of interest exists.

Author contributions

GH, CL, AT, DP, CLHH, HZ and ML contributed to the study design
GW, XT, GH, YN, LW, XJ, GH contributed to the electrophysiological data acquisition.
GW, YD, GH, YX, LW, DL and NH contributed to the data analysis and visualization.
HF, KZ, HZ contributed to the action potential computer simulation.
PM and ML contributed to the molecular docking computer simulation.
LW, DP, ML and GH contributed to the funding and resource acquisition.
ML and GH contributed to the supervision.
All authors contributed to the writing.