Experimental Approach:
We integrated patch-clamp studies utilizing In Vitro ProArrhythmia Assay
(CiPA) Schema IC50 paradigms, molecular modelling,
cardiac multi-electrode array and voltage (RH237) mapping, ECG studies,
and Ca2+ (Rhod-2 AM) mapping in isolated
Langendorff-perfused guinea-pig hearts with human in-silico ion current
modelling.