2.1 Study Approval
All procedures were approved by The Institutional Animals Ethics
Committees at Henan University, Kaifeng, China under and the national
guidelines under which the institution operates, and also conform with
the NIH Guide for the Care and Use of Laboratory Animals. Guinea pigs
(male; 300-350 g) were provided by The Experimental Animal Center of the
Medical College of Xi’an Jiaotong University and maintained in a
pathogen−free facility at Henan University with ad libitum access
to food and water. Animals were humanely sacrificed by intraperitoneal
injection with 3% pentobarbital sodium (50 mg/kg).