Intensity of chemotherapy
The intensity of chemotherapy was classified into four levels according
to the expected duration of severe neutropenia:
- Minimally myelosuppressive chemotherapy: Not expected to induce severe
neutropenia [e.g., maintenance therapy in acute lymphoblastic
leukemia (ALL), chemotherapy for Hodgkin lymphoma]
- Briefly myelosuppressive chemotherapy: Expected duration of severe
neutropenia ≤10 days (e.g., induction, consolidation, interim
maintenance, delayed intensification therapy of standard-risk ALL)
- Strongly myelosuppressive chemotherapy: With the expected duration of
severe neutropenia >10 days (e.g., chemotherapy for acute
myeloid leukemia (AML), and induction, consolidation, interim
maintenance, delayed intensification therapy of high-risk ALL)
- Myeloablative chemotherapy: Requiring hematopoietic stem cell
transplantation (HSCT) to reconstitute bone marrow function (e.g.,
Post HSCT)