Authors’ contributions
X.L. and P.D. conceived the idea, designed and supervised the study, had full access to all data and took responsibility for the integrity of the data. R.M., Q.Z., H.Z., M.C., M.N., Q.S. were responsible for the collection the clinical and laboratory data. S.S. and X.L. analysed data and performed statistical analysis. All authors reviewed and approved the final version.