Figure 1
Figure 1: (A) The bone marrow aspirate demonstrates
hypercellularity for age, trilineage dysplasia with 52%
megakaryoblasts. The megakaryoblasts are described as agranular,
medium-to-large cells with round nucleus, scanty basophilic cytoplasm
with cytoplasmic blebs and pseudopods. Erythropoiesis and granulopoiesis
are suppressed. (B) H & E stain of trephine biopsy (x 40
magnification) shows infiltration of marrow by large clusters of
megakaryoblasts. (C-E) A panel of immunohistochemical staining,
Dako, Denmark (x 40 magnifications) shows positivity for CD34 and CD61
and negativity for MPO. (F) Reticulin stain shows Grade 2
marrow fibrosis.