Figure Legends
Figure 1:
(A) Edematous optic disc with vascular hemorrhage in right eye
(B) Operative image of transconjunctival optic nerve biopsy
Figure 2:
(A) Fine needle aspiration biopsy showed atypical cells (Wright-Giemsa stain, 1000x original magnification)
(B) Optic nerve biopsy showed extensive tumor necrosis and edema with a mild perivascular infiltrate of viable leukemic B lymphoblasts (hematoxylin and eosin, 40x original magnification)
(C) The optic nerve biopsy was immunoreactive for the marker of immaturity, TdT (200x original magnification, dark brown nuclear label)
(D) The optic nerve biopsy was immunoreactive for the B-cell antigen, CD19 (200x original magnification, dark brown cell membrane label)
Supplemental Figure S1: Right optic nerve is thickened and enhanced on axial MRI, with no evidence of leukemic recurrence in brain