(3) Perform simulations
In our research, the fu of imipenem was set to 0.8. The formulas were
organized in Microsoft Excel software. According to formulas (1) and
(6), the imipenem concentration may be assessed after we set thek and V values. The input parameter values included
imipenem concentration (at 5 h and 7.5 h), MIC, Tin , τ and
dosage. The correlation between Cr and
Ca was evaluated (Cr, imipenem
concentration detected by UPLC-MS/MS; Ca, imipenem
concentration assessed by software). The k and V values
may change when the objective function value (OFV) is set to the minimum
value. The drug concentration curve was observed, and the result was
used when Cr and Ca values coincided. We
can obtain f T>MIC from the software.