3.2 Pharmacokinetic and pharmacodynamic parameters assessed
In the model group, the concentrations of imipenem at 5 h and 7.5 h
after the sixth dosing were 5.18±2.99 and 2.64±1.82 μg/ml, respectively.
The f T>MIC calculated by the formula
was 67.26±39.96%, and the f T>4 MICwas 53.93±14.19%. In the non-model group, the concentrations of
imipenem were 6.77±3.84 and 2.19±0.85 μg/ml at the 5 h and 7.5 h time
points, respectively. The f T>MIC andf T>4 MIC were 73.75±23.11% and
41.38±11.25%, respectively. The pharmacokinetic parameters of the two
groups are presented in Table 2.
In our research, the pharmacokinetic and pharmacodynamic parameters
between the two groups were not significantly different. The plasma
concentration curves of the two groups are shown in Fig 2. The detected
imipenem concentration and the simulated concentration curves fit very
well. The results showed that the pharmacokinetic mathematical formula
can be used with modelling software to evaluate the imipenem PK/PD
profiles in patients.