Evaluation of imipenem pharmacokinetic/pharmacodynamic parameters and the impact on antimicrobial outcomes in critically ill patients

Dan Zhang¹, Wenqian Chen¹, Wanyi Xu², Wei Qin¹, Xiaoxue Wang¹, Xianglin Zhang¹, Pengmei Li^1#

1. Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China

2. Department of Pharmacy, Beijing friendship Hospital, Xinhua Campus, Capital, Medical University, Beijing 100029, China

#Corresponding authors : Prof. Pengmei Li, Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China. Tel: 86-010-84205563; E-mail: gelway1216@163.com

Principal Investigator statement: The authors confirm that the Principal Investigator for this paper is Pengmei Li and that she had direct clinical responsibility for patients.

Running head: Imipenem PK/PD parameters in ICU patients