3.2 Pharmacokinetic and pharmacodynamic parameters assessed
In the model group, the concentrations of imipenem at 5 h and 7.5 h after the sixth dosing were 5.18±2.99 and 2.64±1.82 μg/ml, respectively. The f T>MIC calculated by the formula was 67.26±39.96%, and the f T>4 MICwas 53.93±14.19%. In the non-model group, the concentrations of imipenem were 6.77±3.84 and 2.19±0.85 μg/ml at the 5 h and 7.5 h time points, respectively. The f T>MIC andf T>4 MIC were 73.75±23.11% and 41.38±11.25%, respectively. The pharmacokinetic parameters of the two groups are presented in Table 2.
In our research, the pharmacokinetic and pharmacodynamic parameters between the two groups were not significantly different. The plasma concentration curves of the two groups are shown in Fig 2. The detected imipenem concentration and the simulated concentration curves fit very well. The results showed that the pharmacokinetic mathematical formula can be used with modelling software to evaluate the imipenem PK/PD profiles in patients.