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Vaccines and Allergic reactions: the past, the current COVID-19 pandemic, and future perspectives
  • +28
  • Vanitha Sampath,
  • Grace Rabinowitz,
  • Mihir Shah,
  • Surabhi Jain,
  • Zuzana Diamant,
  • Milos Jesenak,
  • Ronald Rabin,
  • Stefan Vieths,
  • Ioana Agache,
  • Domingo Barber Hernández,
  • Sharon Chinthrajah,
  • T. Chivato,
  • William Collins,
  • Thomas Eiwegger,
  • Katie Fast,
  • Wytske Fokkens,
  • Robyn O'Hehir,
  • Markus Ollert,
  • Liam O'Mahony,
  • Oscar Palomares,
  • Oliver Pfaar,
  • CARMEN RIGGIONI,
  • Mohamed Shamji,
  • Milena Sokolowska,
  • Claudia Traidl-Hoffmann,
  • De Yun Wang,
  • Menno van Zelm,
  • Luo Zhang,
  • Cezmi Akdis,
  • Kari Nadeau,
  • María José Torres
Vanitha Sampath
Stanford University School of Medicine

Corresponding Author:[email protected]

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Grace Rabinowitz
Stanford University
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Mihir Shah
Stanford University School of Medicine
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Surabhi Jain
Stanford University
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Zuzana Diamant
Skåne University Hospital Labmedicin Skane
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Milos Jesenak
Jessenius School of Medicine, Comenius University in Bratislava
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Ronald Rabin
Food and Drug Administration Office of Global Regulatory Operations and Policy
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Stefan Vieths
Paul-Ehrlich-Institut,
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Ioana Agache
Transylvania University of Brasov
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Domingo Barber Hernández
Universidad San Pablo CEU
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Sharon Chinthrajah
Stanford Hospital and Clinics
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T. Chivato
Univ CEU San Pablo
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William Collins
Stanford University
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Thomas Eiwegger
The Hospital for Sick Children
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Katie Fast
Stanford University School of Medicine
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Wytske Fokkens
Academic Medical Centre
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Robyn O'Hehir
Alfred Hospital
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Markus Ollert
Luxembourg Institute of Health
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Liam O'Mahony
University College Cork National University of Ireland
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Oscar Palomares
Complutense University of Madrid
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Oliver Pfaar
University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
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CARMEN RIGGIONI
Hospital Sant Joan de Déu
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Mohamed Shamji
Imperial College London
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Milena Sokolowska
University of Zurich Faculty of Medicine
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Claudia Traidl-Hoffmann
Institute of Environmental Medicine, UNIKA-T
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De Yun Wang
Yong Loo Lin School of Medicine, National University of Singapore
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Menno van Zelm
Monash University
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Luo Zhang
Beijing TongRen Hospital, Capital Medical University,
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Cezmi Akdis
University of Zurich
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Kari Nadeau
Stanford University
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María José Torres
Universidad de Málaga Facultad de Medicina
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Abstract

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.
07 Feb 2021Submitted to Allergy
08 Feb 2021Submission Checks Completed
08 Feb 2021Assigned to Editor
09 Feb 2021Reviewer(s) Assigned
24 Feb 2021Review(s) Completed, Editorial Evaluation Pending
04 Mar 2021Editorial Decision: Revise Minor
19 Mar 20211st Revision Received
24 Mar 2021Submission Checks Completed
24 Mar 2021Assigned to Editor
27 Mar 2021Review(s) Completed, Editorial Evaluation Pending
29 Mar 2021Editorial Decision: Accept