|
|
|
|
n=sample
size
|
I:C
|
|
|
Sirey et al. (2017)19
|
USA |
Quantitative (Randomized
clinical effectiveness trial) |
Outpatient |
231 |
(115, 116) |
The
purpose to test the effectiveness of TIP to improve early adherence
among older patients whose primary care physician newly initiated an
antidepressant for depression. |
Medication adherence and depression
severity |
Alekhya et al. (2015)21
|
India |
Quantitative (Cross
sectional study) |
Outpatient |
103 |
|
Study the treatment and disease
factors that influence compliance to the treatment of depression. |
Medication adherence; and disease and treatment factors |
Abegaz et al.
(2017)22
|
Ethiopia |
Quantitative (Prospective
cross-sectional study) |
Inpatient and outpatient |
270 |
|
The purpose
to determine the degree of adverse drug reactions of antidepressants and
their impact on the level of adherence and clinical outcome. |
Adverse
drug reactions, medication adherence, and clinical outcomes
(depression) |
Al-Jumah et al. (2014)23
|
Saudi Arabia |
Quantitative
(Non-experimental cross-sectional design) |
Outpatient |
403 |
|
The
purpose to explore patients’ adherence to antidepressant medication, and
the factors associated with adherence among patients with depression. |
Medication adherence and beliefs about medication |
Ho et al. (2017)24
|
Malaysia |
Qualitative (Grounded
theory methodology) |
Outpatient |
30 |
|
The purpose to explore the
barriers and facilitators of patients’ adherence to antidepressants
among outpatients with MDD. |
Barriers and facilitators of medication
adherence |
Yau et al. (2014)25
|
China |
Quantitative
(Retrospective cohort study) |
Outpatient |
189 |
|
The purpose to
investigate the rate of noncontinuous antidepressant use, subsequent
rate of relapse and recurrence in psychiatric Chinese outpatients, and
factors associated with noncontinuous antidepressant use. |
noncontinuous antidepressant use, factors associated with noncontinuous
antidepressant, and subsequent depression relapse and
recurrence |
Mert et al. (2015)34
|
Turkey |
Quantitative
(Cross-sectional study) |
Inpatient |
203 (n=39 patients with
depression) |
|
The purpose to evaluate factors resulting in medication
nonadherence before admission to the psychiatric service for patients
with psychiatric disorder. |
Socio-demographic and clinical variables,
medication adherence, and reasons of medication
nonadherence |
Al-Jumah et al. (2014)46
|
Saudi Arabia |
Quantitative
(Non-experimental, observational design) |
Outpatient |
403 |
|
The
purpose to investigate the relationship between patient treatment
satisfaction and adherence to antidepressants, and the role of patient
beliefs toward medication in patient treatment satisfaction. |
Medication adherence, treatment satisfaction, and beliefs about
medication |
Aljumah and Hassali (2015)47
|
Saudi Arabia |
Quantitative (Prospective randomized controlled study) |
Outpatient |
239 |
(119, 120) |
The purpose to assess whether pharmacist
interventions based on SDM improved adherence and patient-related
outcomes. |
Medication adherence, beliefs about medication, clinical
outcomes (depression symptoms), patient involvement in decision-making,
quality of life, and treatment satisfaction |
Baeza-Velasco et al. (2019)48
|
France |
Quantitative
(Cross-sectional study) |
Inpatient and outpatient |
360 |
|
The purpose
to explore medication adherence in patients with a major depression
episode, and to identify sociodemographic, clinical, and psychosocial
factors related to adherence status. |
Medication adherence, clinical
and psychosocial factors (depressive symptoms, psychiatric antecedents,
comorbidities, medication, pain, medication side effects, negative life
events, childhood trauma, and attitudes to medication) |
Bhat et al. (2018)49
|
USA |
Quantitative
(Observational retrospective cohort study) |
Outpatient |
258 |
|
The
purpose to evaluate the feasibility of implementing a clinical
pharmacist led multidisciplinary antidepressant telemonitoring service,
evaluate potential opportunities for clinical pharmacy intervention, and
identify which patients with major depressive disorder would be most
likely to benefit from this service in primary care. |
Medication
adherence, adverse effects, suicidal ideations, depressive symptoms, and
pharmacist interventions. |
Burnett-Zeigler et al. (2014)50
|
USA |
Quantitative
(Prospective, observational study) |
Outpatient |
186 |
|
The purpose to
examine the associations between treatment attitudes and beliefs with
race–gender differences in antidepressant adherence. |
Medication
adherence, demographic variables, illness variables (past antidepressant
use, number of prescribed medications, physical health status, mental
health status, comorbid anxiety, somatic anxiety, and depression),
activities of daily living and executive function, attitudes and beliefs
toward depression treatment, and stigma |
Chatterjee et al. (2017)51
|
India |
Quantitative
(Ex-post facto design (criterion-group design)) |
Outpatient |
60 |
|
The purpose to explore belief about the medication influences adherence
to medication, and influence severity of depression and quality of life
of patients with MDD residing at urban and rural areas. |
Medication
adherence, beliefs about medication, depressive symptoms, and quality of
life |
De las Cuevas et al. (2014)52
|
Spain |
Quantitative
(Cross-sectional study) |
Outpatient |
145 |
|
The purpose to identify
potential factors influencing adherence to antidepressant treatment by
patients with mood disorders in the community mental health care
setting. |
Socio-demographic characteristics and clinical variables,
medication adherence, attitudes toward treatment, beliefs about
medication, attitude toward concordance, depressive symptoms, and side
effect |
De Las Cuevas et al. (2014)53
|
Spain |
Quantitative
(Cross-sectional study) |
Outpatient |
119 |
|
The purpose to examine
the relationship of psychological reactance, health locus of control and
the sense of self-efficacy on adherence to treatment regimen among
psychiatric outpatients with depression. |
Socio-demographic
characteristics and clinical variables, medication adherence,
psychological features (psychological reactance, health locus of
control, and self-efficacy) |
Isa et al. (2018)54
|
Nigeria |
Quantitative (Pre-post
one-group intervention study) |
Outpatient |
18 |
|
The purpose to
investigate the effects of psycho-education and basic CBT intervention
on depressed medication-treated adolescents. |
Depressive symptoms,
knowledge of depression, hope, attitudes towards treatment adherence,
and satisfaction |
Klein et al. (2017)55
|
Netherlands |
Quantitative
(Descriptive longitudinal study) |
Outpatient |
289 |
|
The purpose to
explore beliefs about the causes of depression and recovery and to
examine whether they predict antidepressant medication use. |
Medication
adherence, beliefs regarding depression, and antidepressant medication
dosage |
Lu et al. (2016)56
|
China |
Quantitative
(Cross-sectional study) |
Outpatient |
135 |
|
The purpose to
investigate the variables associated with adherence with antidepressants
in elderly Chinese patients, focusing on attitudes and beliefs as
potential predictors, as well as sociodemographic characteristics and
illness-related variables. |
Medication adherence and beliefs about
medication |
Lucca et al. (2015)57
|
India |
Quantitative
(Cross-sectional study) |
Outpatient |
400 (n=170 patients with
depression) |
|
The purpose to determine the incidence and factors
associated with medication nonadherence among psychiatric outpatients. |
Medication adherence and reasons for medication
nonadherence |
Novick et al. (2015)58
|
Six East Asian countries and
regions (China, Hong Kong, Malaysia, Singapore, South Korea, and Taiwan) |
Quantitative (Cross-sectional study, prospective, observational study) |
Inpatient |
430 |
|
The purpose to describe pharmacological treatment
patterns in patients with MDD. |
Medication adherence, reasons for
medication nonadherence, depressive symptoms, somatic symptom, and
quality of life |
Serrano et al. (2014)59
|
Spain |
Quantitative
(Observational and longitudinal study) |
Outpatient |
29 |
|
The purpose
to determine the degree of therapeutic adherence in patients with
depression, examine factors involved in the adherence process, and
observe the clinical outcome. |
Medication adherence, depressive
symptoms, drug attitude, beliefs about medication, and
personality |
Shrestha Manandhar et al. (2017)60
|
Nepal |
Quantitative (Prospective study) |
Inpatient and outpatient |
60 |
|
The
purpose to determine the medication adherence pattern in patients with
depression and assess the factors associated with non-adherence to the
prescribed antidepressant therapy. |
Medication adherence and medication
adherence pattern |
Taleban et al. (2016)61
|
Iran |
Quantitative
(Randomized clinical trial) |
Outpatient |
198 |
Booklet and text
messaging group (67), booklet (66), and control (65) |
The purpose to
evaluate the impacts of text messaging interventions, which aimed to
inspire the affected patients to peruse bibliotherapy. |
Medication
adherence and depression severity |
Vannachavee et al. (2016)62
|
Thailand |
Quantitative
(Randomized controlled trial with two parallel-group posttest-only
designs) |
Outpatient |
56 |
(30,26) |
The purpose to examine the effect
of DAEP on adherence behaviors in patients with first diagnosed major
depressive disorder. |
Medication adherence and depression
severity |
Bushnell et al. (2016)63
|
USA |
Quantitative
(Retrospective cohort study) |
Inpatient and outpatient |
8,837 |
|
The
purpose to identify predictors of six-month antidepressant persistence. |
Antidepressant persistence, demographic, clinical, and psychosocial
factors (age, sex, psychiatric and non-psychiatric co-morbidities,
healthcare utilization, antidepressant class, prior suicide attempt,
high and mid-potency prescription opiate usage, and recurrent MDD
diagnosis) |
Green et al. (2017)64
|
USA |
Mixed-method |
Outpatient |
28 |
|
The purpose to investigate knowledge and attitudes
about antidepressant medication, including risks and benefits, how
patients received this information, and how they would prefer to learn
about antidepressants. |
Medication persistence, knowledge and attitudes
about antidepressant medication, Depression, Trauma exposure,
post-traumatic stress disorder, and side effects |
Grover et al. (2018)65
|
India |
Quantitative
(Naturalistic, longitudinal, follow‑up study) |
Outpatient |
140 |
|
The
purpose to evaluate the medication adherence, treatment adherence, and
outcome of depression. |
Medication adherence, treatment adherence, and
outcome of depression |
Holvast et al. (2019)66
|
Netherlands |
Quantitative
(Longitudinal study) |
Outpatient |
1,512 |
|
The purpose to determine
the non-adherence rates to antidepressants among older adults in primary
care, based on non-initiation, suboptimal implementation or
non-persistence. |
Non-initiation, suboptimal implementation,
non-persistence, associated with non-adherence |
Klang et al. (2015)67
|
Israel |
Quantitative
(Prospective, nonrandomized, open-label, naturalistic observational
study) |
Outpatient |
4246 |
(173, 4079) |
The purpose to effectiveness
of CP intervention for patients with MDD. |
Medication adherence and
depressive symptoms |
LeBlanc et al. (2015)68
|
USA
|
Quantitative (Cluster randomized trial)
|
Outpatient
|
Clinicians (117);
patients (297)
|
Clinicians (66, 51); patients (158, 139)
|
The purpose to estimate the effect of DMC on quality of the
decision‐making process and depression outcomes.
|
Patient knowledge and involvement in decision making, patient and
clinician decisional comfort and satisfaction, encounter duration,
medication adherence, and depression symptoms
|
Slabbert et al. (2015)69
|
South Africa |
Quantitative
(Prospective, descriptive cohort study) |
Outpatient |
14,135 |
|
The
purpose to investigate the prevalence of antidepressant non-compliance
in the private healthcare sector of South Africa. |
Medication
adherence |
Zhang et al. (2016)70
|
China |
Quantitative
(Retrospective cohort study) |
Inpatient and outpatient |
8,484 |
|
The
purpose to investigate medication usage patterns, health care resource
utilization, and direct medical costs of patients with MDD in Beijing,
People’s Republic of China. |
Medication usage patterns, health care
resource utilization, and economic burden |
Hammonds et al. (2015)71
|
USA |
Quantitative
(Randomized, parallel-group clinical trial) |
Outpatient |
57 |
(30, 27) |
The purpose to determine the effect of medication reminding via
smartphone app on adherence to antidepressant medications in college
students. |
Medication adherence, depression, social support, stress,
and health beliefs |
Pradeep et al. (2014)72
|
India |
Quantitative
(Randomized trial) |
Outpatient |
260 |
(122, 138) |
The purpose to
investigate effectiveness of enhanced care in improving treatment
seeking and adherence to antidepressant medication in women with
depression living in rural India. |
Medication adherence, number of
clinic visits, depressive symptoms, and quality of life |
Srimongkon et al. (2018)73
|
Australia |
Qualitative
(Phenomenological approach) |
Outpatient |
23 |
|
The purpose to explore
factors which facilitate and negatively impact adherence, at initiation,
implementation and discontinuation phases of adherence to antidepressant
medication. |
Facilitate and negatively impact adherence |
Vargas et al. (2015)74
|
USA |
Qualitative
(Ethnography) |
Outpatient |
30 |
|
The purpose to examines salient
views of depression and pharmacotherapy among Latinos seeking outpatient
antidepressant therapy and suggests possible strategies for engaging
patients on these views prior to the onset of treatment. |
Views of
depression and antidepressant medication |