Author (year) Country Intervention Categories Outcomes
Sirey et al. (2017)19 USA TIP Program Multi-faceted (Cognitive education and information; and behavioral counselling) TIP Program is an effective intervention to improve early adherence to pharmacotherapy. Also, interventional group were 5 times more likely to be adherent at 6 weeks and were 3 times more likely to be adherent to their antidepressant pharmacotherapy at both 6 and 12 weeks. Furthermore, interventional group showed a significant reduction in depressive symptoms.
Aljumah and Hassali (2015)47 Saudi Arabia Pharmacist interventions SDM Education and information Pharmacist interventions based on SDM, intervention group showed significant differences in adherence to medication, treatment satisfaction, general overuse beliefs, specific concern beliefs, and total general beliefs about medicines. However, severity of depression and quality of live were not significantly change between intervention and control group at the end of six months. After 6 months, intervention group patients showed statistically significant in adherence to antidepressants and treatment satisfaction, and a decrease in concern beliefs and general beliefs about medicines.
Bhat et al. (2018)49
USA
A pharmacist-led multidisciplinary telemonitoring service
Multi-faceted (Education and information; and monitor feedback (adherence and disease)) The clinical pharmacist-led multidisciplinary antidepressant telemonitoring service is a resource to monitor patients after antidepressant initiation or uptitration in primary care settings and provided interventions for patients. However, unable to strongly assess the impact of clinical pharmacists’ interventions.
Isa et al. (2018)54 Nigeria Psycho-education and basic CBT strategies Multi-faceted (Cognitive education and information; and behavioral counselling) The effect of a psycho-educational and basic CBT intervention resulted in reduction in depressive symptoms, improvements in knowledge of depression, hope, and attitude towards treatment adherence one week and four weeks after the intervention.
Taleban et al. (2016)61 Iran Bibliotherapy and text messaging Counselling (Cognitive behavioral interventions) Based on treatment compliance not significantly affected through group, but factors interactive effect of group factor and the time factor was statistically significant. Neither of the groups showed significant variations of the treatment compliance in different times comprising before the treatment, after the treatment or during the following up procedure. However, intensity of depressive symptoms was significantly affected through time and group factors as well as time‑group interaction. Neither of the interventional groups differed in intensity of depressive symptoms.
Vannachavee et al. (2016)62 Thailand DAEP Multi-faceted (Motivational interviewing; and cognitive and behavioral counselling) The participants in the experimental group had more correct drug adherence behaviors in terms of the dosage and timing during the sixth week than that of the participants in the control group. Also, the patients who received the DAEP had better depression scores after the intervention than those who received only the usual care.
Klang et al. (2015)67
Israel
CPs management
Multi-faceted (Education and information, reminders, and monitor feedback (adherence and disease))
Measure adherence to antidepressant treatment at 6 months. At 1 month, the adherence rate was 71% in the CP group and at 6 months, the rates were high (55%) than control group of 42%. At 1 month, the adherence rate was 57% in the control group and at 6 months, the rate was 15.2%.
LeBlanc et al. (2015)68 USA DMC Education and information The use of DMC by primary care clinicians and patients with moderate to severe depression during clinical encounters was feasible and effectively improved patient knowledge and engagement in the decision-making process, as well as patient and clinician satisfaction with that process. However, use of the decision aid, had no discernible effect on encounter duration, depression control, and medication use and adherence.
Hammonds et al. (2015)71 USA Electronic medication reminder application Reminders Participants use of a medication reminder app were 3.5 times more likely to adhere to their medication regimen than those in the control group. However, depression symptoms were reduced from baseline, but the magnitude of change was not greater in participants using the medication reminder app.
Pradeep et al. (2014)72
India
Community care support
Multi-faceted (Education and information; and monitor feedback (adherence and disease))
The number of clinic related visits and the duration of treatment (as measured by the number of weeks that subjects took antidepressant medication) was significantly greater in the interventional group compared to control group. While there was a significant difference in the treatment adherence pattern between the two groups, there was no significant difference in the outcomes of depression and quality of life at six months follow up.