Study Population
This was a retrospective single institutional analysis that included
adult patients (18 years or older) who underwent cardiac surgery at a
multi-hospital health system between January 2011 and June 2018.
Patients were included if they were placed on CPB during the case and
had a perfusion time of 300 minutes or greater. For patients requiring
multiple CPB runs, the cumulative time on CPB was calculated and
utilized for analysis. Patients requiring circulatory arrest were
excluded. This study was approved by the Institutional Review Board at
the University of Pittsburgh (MOD18120143-003, approved 3/9/2020).
Patient consent was waived due to retrospective nature of the study.