Figure Legends
Figure 1: Overview of IgG antibodies. A) Structure of IgG showing light (L) chains and heavy (H) chains in pink and purple, respectively. The glycan-modification position N297 is depicted with red stars. B) N-glycan structure of monoclonal antibodies in different species. Abbreviations : NeuAc: N-acetylneuraminic acid, Man: mannose, Fuc: fucose, GlcNAc: N-acetylglucosamine, Gal: galactose. Adapted from Gomord et al ., 2010.
Figure 2: Summary of Quality-by-Design milestones. Taken from ICHQ11 guidelines document.
Table 1: Characteristics of different routes of administration (RoA) for monoclonal antibodies. Data gathered from Ortega et al. (2017), Ryman & Meibohm (2017) and Zhao et al. (2013).
Table 2: Characteristics (route of administration, mode of delivery and dose strength) of several therapeutic mAbs approved by the FDA. Abbreviations: RoA: route of administration; IV: intravenous; SC: subcutaneous; IVP: intravenous pyelogram; PFS: pre-filled syringe; AI: autoinjector. Information gathered from MedScape (2020).