Figure Legends
Figure 1: Overview of IgG antibodies. A) Structure of
IgG showing light (L) chains and heavy (H) chains in pink and purple,
respectively. The glycan-modification position N297 is depicted with red
stars. B) N-glycan structure of monoclonal antibodies in
different species. Abbreviations : NeuAc: N-acetylneuraminic
acid, Man: mannose, Fuc: fucose, GlcNAc: N-acetylglucosamine, Gal:
galactose. Adapted from Gomord et al ., 2010.
Figure 2: Summary of Quality-by-Design milestones. Taken from
ICHQ11 guidelines document.
Table 1: Characteristics of different routes of administration
(RoA) for monoclonal antibodies. Data gathered from Ortega et al.
(2017), Ryman & Meibohm (2017) and Zhao et al. (2013).
Table 2: Characteristics (route of administration, mode of
delivery and dose strength) of several therapeutic mAbs approved by the
FDA. Abbreviations: RoA: route of administration; IV:
intravenous; SC: subcutaneous; IVP: intravenous pyelogram; PFS:
pre-filled syringe; AI: autoinjector. Information gathered from MedScape
(2020).