Publication bias
For the primary outcome referring to ACE inhibitors, funnel plot did not
show apparent visual asymmetry (Supplementary figure 2). The Begg tests
showed no evidence of publication bias (P=0.66). As for the primary
outcome referring to ARBs, funnel plots did not show any asymmetrical
tail (Supplementary figure 3). Likewise, Begg tests showed no evidence
of publication bias (P=0.21). For the secondary outcome, funnel plot did
not show visual asymmetry (Supplementary figure 4).; testing for
publication bias showed similar results (Begg’s P-value for asymmetry
1.00). As for the COVID-16 studies referring to primary outcome, Begg’s
test for asymmetry was also not significant (P =0.08).