Subject characteristics
Subject characteristics of the discovery and replication cohorts are shown in Table 1. Regarding the discovery cohort, the median [range] duration of follow-up of the entire population was 39 [4-49] years. Most of the subjects (n=76) were from the study described by Carpaijet al .4 at the third visit; the remaining (n=27) were remission subjects added to this study to further enrich remission cases. Of the 103 subjects included in this study, 54 (52.4% of total subjects) had ClinR, and 20 of these had ComR (19.4% of total subjects). At baseline, subjects in remission later had higher FEV1 and FVC level compared to PersA (Figure S1). Within the whole dataset, 72 subjects (44 PersA, 28 ClinR and 10 ComR) had whole blood methylation data and 97 (44 PersA, 53 ClinR and 19 ComR) had nasal methylation data, with 66 subjects providing both (Figure 1).