Phenotype Definition
The presence of PersA, ClinR and ComR was determined at the most recent visit. ClinR was defined according to the following criteria: 1) No use of any asthma medication, and 2) no symptoms (asthma attacks and/ or wheezing) in the past year. ComR was defined as ClinR combined with 3) no AHR (PC20 (provocative concentration causing a 20% fall in FEV1 (forced expiratory volume in 1 s)) methacholine ⩽ 39.3 mg·mL−1)), and/or 4) FEV1% predicted pre-bronchodilator > 80%. PersA was defined as the presence of asthma symptom and/or the use of asthma medication. Detailed phenotype definitions of the replication cohorts are described in the supplemental materials.