9.6 Potent receptor for SARS COV-2- ACE2
Coronaviruses used to enter host cell by two distinct
routes,73 the first possible route is cell mediated
endocytosis. The surface spike S glycoproteins has been accepted as key
determinant, for coronaviruses entry, with S1 domain mediating the
binding of receptor and domain S2 is responsible for membrane fusion of
cell.58 The second possible route is that spike
protein S is being cleaved by S-activating protease co-expressed with
the host cell receptor, thereby inducing the direct fusion of cellular
and viral membrane.67
10 TRANSMEMBRANE SPIKE (S)
GLYCOPROTEINS