9.6 Potent receptor for SARS COV-2- ACE2
Coronaviruses used to enter host cell by two distinct routes,73 the first possible route is cell mediated endocytosis. The surface spike S glycoproteins has been accepted as key determinant, for coronaviruses entry, with S1 domain mediating the binding of receptor and domain S2 is responsible for membrane fusion of cell.58 The second possible route is that spike protein S is being cleaved by S-activating protease co-expressed with the host cell receptor, thereby inducing the direct fusion of cellular and viral membrane.67

10 TRANSMEMBRANE SPIKE (S) GLYCOPROTEINS