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SARS-CoV-2, COVID-19, skin and vascular system - what do we know so far?
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  • Natalija Novak,
  • Wenming Peng,
  • Mirjam Naegeli,
  • Christina GalvanOrcid,
  • Isabel Kolm-Djamei,
  • Charlotte Brüggen,
  • Beatriz Cabanillas,
  • Peter Schmid-Grendelmeier,
  • Alba Catala
Natalija Novak
University of Bonn
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Wenming Peng
University of Bonn
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Mirjam Naegeli
University Hospital Zurich
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Christina Galvan
Orcid
Mostoles University Hospital
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Isabel Kolm-Djamei
University Hospital Zurich
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Charlotte Brüggen
University Hospital Zurich
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Beatriz Cabanillas
University of Bonn
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Peter Schmid-Grendelmeier
University of Zurich Hospital
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Alba Catala
Hospital Plato
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Peer review status:ACCEPTED

08 Jun 2020Submitted to Allergy
10 Jun 2020Submission Checks Completed
10 Jun 2020Assigned to Editor
12 Jun 2020Reviewer(s) Assigned
22 Jun 2020Review(s) Completed, Editorial Evaluation Pending
22 Jun 2020Editorial Decision: Revise Minor
29 Jun 20201st Revision Received
30 Jun 2020Submission Checks Completed
30 Jun 2020Assigned to Editor
01 Jul 2020Reviewer(s) Assigned
01 Jul 2020Review(s) Completed, Editorial Evaluation Pending
06 Jul 2020Editorial Decision: Accept

Abstract

The pandemic condition Coronavirus-disease (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can take asymptomatic, mild, moderate, and severe courses. COVID-19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Different clinical symptoms caused by involvement of organs outside the respiratory system have been also described. Interestingly, reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS-CoV-2 positive patients as such features outside the respiratory sphere, are rapidly emerging. However, knowledge about prevalence and pattern of skin involvement, time of onset, predilection, and its direct or indirect relation to SARS-CoV-2 is still limited. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID-19 patients, discuss potential causative factors and describe differential diagnostic evaluations.