Conflict of interest
The authors declare no conflict of interest
Figure legend.
Figure 1. Schematic representation of the lipid-nanoparticle PEGylated with PEG-2000 contained in mRNA vaccines for COVID-19 (left part). PEG-2000/lipid conjugate (individual unit) or PEGylated nanoparticle could be involved in the allergic reactions to the mRNA vaccines for COVID-19. The potential mechanisms involved (direct IgE-mediated degranulation or CARPA) are depicted in the right-upper part. PEG in its native form could not be as immunoreactive as PEG-2000/lipid conjugates (right-lower part).