Rational, aims, and objectives: To probe into the status of medication adherence in patients after PCI and its correlation with health literacy. Methods: A total of 260 patients after PCI in cardiology department of three hospitals in Zhengzhou, were investigated by two questionnaire, which are 8-item Morisky Medication Adherence Scale and Chronic Disease Health Literacy Scale. Results: The score of medication adherence was 5.21±2.04, the score of health literacy was 80.8±24.43; Multivariate linear regression analysis results showed that degree of education, the number of hospitalization, monthly income, course of diseases were the influencing factors of medication adherence, which could explain 61.2% of the total variation; The medication adherence in patients after PCI was positively correlated with health literacy. Conclusion: The higher levels of health literacy positively influenced medication adherence scores in patients after PCI. Nursing staff should assist the patients after PCI to establish self-health management awareness, in order to improve their medication adherence.