Conclusions
The simulation work presented here leverages the known kinetics of the
SARS-CoV-2 life cycle to rank potential targeted approaches with a focus
on the likely need to combine repurposed, low-potency agents. These
simulations suggest early intervention is critical and targeting
multiple points important to viral replication within and release from
infected host cells is a good strategy for reducing both viral load and
host cell infection. In addition, we observed that the time-window
opportunity for a therapeutic intervention to effect duration of viral
shedding exceeds the effect on sparing epithelial cells from infection
or impact on viral load AUC. Furthermore, the impact on reduction on
duration of shedding may extend further in patients who exhibit a
prolonged shedder phenotype.