Author contributions
Dr
Nan Bai designed the cardiac safety portions and SAD, MAD sudies, and
oversaw their statistical analysis and interpretation. Ms Jin Wang
assisted with interpretation of the data and performed the statistical
analysis of the cardiac safety data. Ms Haoyue Che assisted in the
interpretation of data and writing articles. Dr Hai Wang, Dr Rui Wang,
were responsible for the overall conduct and interpretation of the two
trials. Dr Yun Cai were responsible for data proofreading and writing
articles.