Author contributions
Dr Nan Bai designed the cardiac safety portions and SAD, MAD sudies, and oversaw their statistical analysis and interpretation. Ms Jin Wang assisted with interpretation of the data and performed the statistical analysis of the cardiac safety data. Ms Haoyue Che assisted in the interpretation of data and writing articles. Dr Hai Wang, Dr Rui Wang, were responsible for the overall conduct and interpretation of the two trials. Dr Yun Cai were responsible for data proofreading and writing articles.