Celecoxib
COX-2 is constitutively overexpressed in association with acute and chronic inflammation and also in malignant tumors58. Inflammation induced by pathogens and in response to disordered metabolic states such as obesity is associated with expression of COX-259. Prostaglandin and proinflammatory cytokine production is limited by COX-2 which results in a down-regulation of the cytokine storm60 and angiogenesis61 ,62 ,63. It is reported that celecoxib modulates IκBα degradation and phosphorylation and suppresses IKK activity in a dose-dependent manner64.