Celecoxib
COX-2 is constitutively overexpressed in association with acute and
chronic inflammation and also in malignant tumors58.
Inflammation induced by pathogens and in response to disordered
metabolic states such as obesity is associated with expression of
COX-259. Prostaglandin and proinflammatory cytokine
production is limited by COX-2 which results in a down-regulation of the
cytokine storm60 and angiogenesis61
,62 ,63. It is reported that celecoxib modulates IκBα degradation and
phosphorylation and suppresses IKK activity in a dose-dependent
manner64.