Introduction
SARS-CoV-2 infection causing COVID-19 in sickle cell disease (SCD) is
still being described. Severe COVID-19 includes a broad spectrum of
illness, including excessive pro-inflammatory cytokine release with
multisystem hyperinflammation, vasculitis, and
coagulopathy1; many die from ARDS, thromboembolic
complications, or multiorgan failure2,3,4. Although
acute chest syndrome and vaso-occlusive pain crisis (VOC) in SCD
patients with COVID-19 have been reported5, we present
a unique case of hepatic encephalopathy, hyperammonemia, and multisystem
inflammation with multiorgan failure in a SCD patient following
COVID-19.