background. Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and platelet activation.To study whether there is a relationship between inflammatory process and platelet activation in CSU patients. Methods. Circulating concentrations of hsCRP ,basophil count and mean platelet volume (MPV) were measured in patients with CSU of varying severity as well as in healthy subjects, and we analyzed the relationship between markers and the disease severity and the correlation between markers. Results. The levels of hsCRP and MPV were elevated in patients with CSU,and patients with CSU displayed significantly lower levels of basophil count than the controls. The levels of hsCRP, basophil count and MPV were associated with disease severity. A signiﬁcant association was found between MPV and hsCRP concentrations in patients with CSU, and basophil count were respectively correlated with MPV and hsCRP. Conclusions. There may be an interplay between inflammatory process and platelet activation in the pathogenesis of CSU.