Interplay between inflammatory process and platelet activation in
chronic spontaneous urticaria
Abstract
background. Chronic spontaneous urticaria (CSU) is associated with
activation of systemic inflammatory response and platelet activation.To
study whether there is a relationship between inflammatory process and
platelet activation in CSU patients. Methods. Circulating concentrations
of hsCRP ,basophil count and mean platelet volume (MPV) were measured in
patients with CSU of varying severity as well as in healthy subjects,
and we analyzed the relationship between markers and the disease
severity and the correlation between markers. Results. The levels of
hsCRP and MPV were elevated in patients with CSU,and patients with CSU
displayed significantly lower levels of basophil count than the
controls. The levels of hsCRP, basophil count and MPV were associated
with disease severity. A significant association was found between MPV
and hsCRP concentrations in patients with CSU, and basophil count were
respectively correlated with MPV and hsCRP. Conclusions. There may be an
interplay between inflammatory process and platelet activation in the
pathogenesis of CSU.