2. Inhibitors of Epithelium Cell Entry
It has been widely reported that angiotensin-converting enzyme 2 (ACE2) is likely to be the predominant cell surface receptor by which SARS-CoV-2 is able to enter host cells (Hoffmann et al., 2020). ACE2 is widely distributed in the body, but is particularly highly expressed on lung alveolar cells, which could explain the increased lung damage seen in some COVID-19 patients (Favalli et al., 2020; Zhao et al., 2020).