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Insight into the Pediatric and Adult Dichotomy of COVID-19: Age-Related Differences in the Immune Response to SARS-CoV-2 infection
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  • Allison Fialkowski,
  • Yael Gernez,
  • Puneeta Arya,
  • Katja Weinacht,
  • T. Bernard Kinane,
  • Lael Yonker
Allison Fialkowski
Harvard Medical School
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Yael Gernez
Stanford University
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Puneeta Arya
Massachusetts General Hospital
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Katja Weinacht
Stanford University
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T. Bernard Kinane
Massachusetts General Hospital for Children
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Lael Yonker
Massachusetts General Hospital
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Peer review status:UNDER REVIEW

15 Jun 2020Submitted to Pediatric Pulmonology
15 Jun 2020Submission Checks Completed
15 Jun 2020Assigned to Editor
19 Jun 2020Reviewer(s) Assigned
28 Jun 2020Review(s) Completed, Editorial Evaluation Pending
09 Jul 20201st Revision Received
10 Jul 2020Assigned to Editor
10 Jul 2020Submission Checks Completed
10 Jul 2020Reviewer(s) Assigned

Abstract

The difference in morbidity and mortality between adult and pediatric COVID-19 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to SARS-CoV-2 is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of MIS-C. The goal of this review is to highlight research developments in understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.