Biomarkers associated with peanut allergy at 7-11 years
Logistic regression analyses was used to determine if any covariates
were found to be related to developing PA at 7-11y. Demographic and
clinical characteristics such as age, sex, ethnicity or history of AD
were not significantly associated with PA at 7-11y. Univariate analyses
were performed and the following covariates were found to be
significant: childhood asthma at 7-11y, SPT to peanut at 12m, 36m and
7-11y, peanut-sIgE at 3y and 7-11y, Ara h 2-sIgE at 3y and MAT to peanut
at 3y and 7-11y (Supplementary Appendix Table S4).
With the multivariable regression models, when comparing all biomarkers
at each of the time points, only peanut SPT at 7-11y was associated with
increased odds of having PA at 7-11y (coeff 0.72, 95% CI 0.1, 1.3)
(Supplementary Appendix Table S5). When looking at the model that looked
at individual biomarkers across time, only SPT, specifically at the
7-11y time point was significantly associated with PA status at 7-11y
(coeff 0.9, 95% CI 0.2, 1.6). Small numbers of children who developed
new PA or resolved their PA prevented longitudinal analyses.