Persistent peanut allergy (n=18) | New peanut allergy (n=2) | Outgrown peanut allergy (n=1) | No peanut allergy (n=27) |
P value
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Peanut SPT mm (IQR) | Peanut SPT mm (IQR) | Peanut SPT mm (IQR) | Peanut SPT mm (IQR) | Peanut SPT mm (IQR) | Peanut SPT mm (IQR) |
3 months* 12 months 36 months 7-11 years | 0 (0, 0) 5.8 (3.5, 8) 8.8 (7, 10.5) 9.3 (7.5, 10.5) | 0 (0, 0) 1 (0, 2) 1.3 (0, 2.5) 7 (4, 10) | – 5.5 8.0 0 | 0 (0, 2) 1 (0, 4.5) 1 (0, 5) 0 (0, 2) | – 0.02 <0.001 <0.001 |
Peanut specific IgE (kUA/L) | Peanut specific IgE (kUA/L) | Peanut specific IgE (kUA/L) | Peanut specific IgE (kUA/L) | Peanut specific IgE (kUA/L) | Peanut specific IgE (kUA/L) |
3 months 12 months 36 months 7-11 years | 0.05 (0.0, 0.3) 1.5 (0.9, 7.2) 9.5 (6.1, 46.7) 30.0 (4.2, 85.4) | 0.03 (0.03, 0.03) 0.4 (0.1, 0.8) 0.7 (0.2, 1.3) 11.7 (2.9, 20.5) | 0.08 1.3 0.01 0.02 | 0.05 (0.0, 0.3) 1.6 (1.1, 5.4) 0.9 (0.2, 1.5) 0.6 (0.1, 4.9) | 0.41 0.28 <0.001 <0.001 |
Peanut components specific IgE (kUA/L) | Peanut components specific IgE (kUA/L) | Peanut components specific IgE (kUA/L) | Peanut components specific IgE (kUA/L) | Peanut components specific IgE (kUA/L) | Peanut components specific IgE (kUA/L) |
3 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 | 0.07 (0, 0.4) 0.01 (0.01, 2.0) 0.02 (0.002, 0.04) 0.003 (0.002, 0.005) | 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) | 0.01 0.01 0.01 0.01 | 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) | 0.91 0.93 0.87 0.99 |
12 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 | 0.3 (0.05, 4.0) 0.8 (0.07, 6.7) 0.08 (0.02, 0.3) 0.001 (0, 0.01) | 0.3 (0.01, 0.6) 0.1 (0.01, 0.1) 0.02 (0.01, 0.03) 0.01 (0.01, 0.01) | 0.06 1.7 0.01 0.01 | 0.2 (0.02, 0.6) 0.1 (0.01, 0.7) 0.1 (0.03, 0.4) 0.01 (0.01, 0.01) | 0.47 0.13 0.26 0.92 |
36 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 | 0.04, 2.4) 9.3 (1.4, 31.9) 0.05 (0.02, 0.6) 0.01 (0, 0.01) | 0.04 (0.02, 0.1) 0.03 (0.01, 0.04) 0.03 (0.03, 0.03) 0.05 (0.01, 0.09) | 0.01 0.01 0.01 0.01 | 0.1 (0.03, 0.2) 0.04 (0.01, 0.2) 0.1 (0.05, 0.2) 0.04 (0.01, 0.05) | 0.21 <0.001 0.31 0.28 |
7-11 years Ara h 1 Ara h 2 Ara h 3 Ara h 6 Ara h 8 | 2.0 (0.1, 35.7) 19.8 (1.9, 60.5) 0.3 (0.01, 3.9) 13.0 (2.3, 32.4) 0.5 (0, 7.9) | 1.3 (0.3, 2.4) 6.4 (0.1, 12.8) 0.19 (0.2, 0.3) 1.5 (0.05, 2.9) 48.7 (2.6, 94.9) | 0.01 0.01 0.01 0.01 0.01 | 0.02 (0.01, 0.1) 0.04 (0.01, 0.1) 0.04 (0.01, 0.1) 0.04 (0.01, 0.1) 0.1 (0.01, 0.6) | <0.001 <0.001 0.05 <0.001 0.16 |
Peanut-specific IgG4 and specific IgG4:IgE Ratios | Peanut-specific IgG4 and specific IgG4:IgE Ratios | Peanut-specific IgG4 and specific IgG4:IgE Ratios | Peanut-specific IgG4 and specific IgG4:IgE Ratios | Peanut-specific IgG4 and specific IgG4:IgE Ratios | Peanut-specific IgG4 and specific IgG4:IgE Ratios |
Peanut sIgG4 (g/L) 3 months 12 months 36 months 7-11 years | 6.1 (0, 52.8) 202.9 (102, 436.8) 494.2 (215.9, 1800.6) 736.2 (217.2, 1361.3) | 15.2 (15.2,15.3) 233.7 (37.1, 430.3) 121.1 (23.3, 218.8) 840.9 (840.9, 1613.4) | - - 99.3 44.3 | 8.4 (0, 27.3) 84.8 (34.5, 506.9) 386.5 (96, 2171.5) 719 (127.9, 2685) | 0.66 0.37 0.35 0.43 |
Peanut specific IgG4:IgE ratios 3 months 12 months 36 months 7-11 years | 4.4 (0, 63.6) 30.4 (6.7, 78.2) 14.7 (7.5, 21.1) 10.4 (4.5, 37.4) | 211.7 (211.1, 212.4) 213.2 (193.5, 232.9) 60.6 (51, 70.1) 21.3 (9.8, 32.8) | - - 4135.9 1044.8 | 20.5 (0, 326.2) 17.9 (6.1, 296.4) 175.8 (39.6, 1222.7) 483 (30.4, 2448.0) | 0.39 0.22 0.03 <0.01 |
Mast cell activation to peanut (%CD63+ LAD2 cells) | Mast cell activation to peanut (%CD63+ LAD2 cells) | Mast cell activation to peanut (%CD63+ LAD2 cells) | Mast cell activation to peanut (%CD63+ LAD2 cells) | Mast cell activation to peanut (%CD63+ LAD2 cells) | Mast cell activation to peanut (%CD63+ LAD2 cells) |
12 months 36 months 7-11 years | 4.6 (0.16, 25.2) 17.8 (3.1, 30.3) 12.7 (7.6, 38.9) | 0.1 (0.01, 0.2) 0.3 (0.3, 0.4) 0.2 (0.1, 0.4) | – 0.01 0.5 | 0.3 (0.01, 3.3) 0.2 (0.01, 0.6) 0.2 (0.01, 0.8) | 0.20 <0.001 <0.001 |
At the 3m time point, only children in the early introduction group had SPT performed. | *At the 3m time point, only children in the early introduction group had SPT performed. | *At the 3m time point, only children in the early introduction group had SPT performed. | *At the 3m time point, only children in the early introduction group had SPT performed. | *At the 3m time point, only children in the early introduction group had SPT performed. | *At the 3m time point, only children in the early introduction group had SPT performed. |