Biomarkers associated with peanut allergy at 7-11 years
Logistic regression analyses was used to determine if any covariates were found to be related to developing PA at 7-11y. Demographic and clinical characteristics such as age, sex, ethnicity or history of AD were not significantly associated with PA at 7-11y. Univariate analyses were performed and the following covariates were found to be significant: childhood asthma at 7-11y, SPT to peanut at 12m, 36m and 7-11y, peanut-sIgE at 3y and 7-11y, Ara h 2-sIgE at 3y and MAT to peanut at 3y and 7-11y (Supplementary Appendix Table S4).
With the multivariable regression models, when comparing all biomarkers at each of the time points, only peanut SPT at 7-11y was associated with increased odds of having PA at 7-11y (coeff 0.72, 95% CI 0.1, 1.3) (Supplementary Appendix Table S5). When looking at the model that looked at individual biomarkers across time, only SPT, specifically at the 7-11y time point was significantly associated with PA status at 7-11y (coeff 0.9, 95% CI 0.2, 1.6). Small numbers of children who developed new PA or resolved their PA prevented longitudinal analyses.