3.1 Study and data selection
The flowchart of the detailed search process is illustrated in Figure 1.
Initially, 397 potentially studies were identified, of which 73 were
duplicates and 233 were excluded after reviewing the titles and
abstracts. Of the remaining 91 studies, 17 review articles, 3
editorial/letters, and 8 case reports or case series, and 21 abstracts
were excluded. Further, 33 studies were excluded after a detailed
evaluation of the full text for the following reasons: 9 were
uncontrolled studies, 5 were clinical studies design, 13 lacked study
endpoints, 6 reporting duplicate data. And then, 2 trails by Berte B et
al and Dhillon G et al15,16 comparing HPSD vs. LPLD
were also excluded, because their ablation were guided by ablation index
(AI) without illustrating ablation time per site detailed. Consequently,
7 clinical trials with 2023 patients were enrolled in this
meta-analysis4,13,14,17-20.