Does abnormal baseline LFTs independently predict death or
mechanical ventilation during hospitalization with COVID-19 infection?
A multivariate logistic regression was then performed to ascertain the
effects of age, different background illnesses and abnormal baseline
LFTS on the primary outcome measure - composite endpoint of death or
requirement for mechanical ventilation during hospitalization. Results
are presented in table (3) below.
During the 4-month span of the study and out of the 444 subjects
hospitalized with COVID-19 in our tertiary care center, 32 (7.2%)
patients died and 21 (4.7%) required mechanical ventilation. The
overall composite endpoint was identified in 49 (11%) subjects.
Univariate analysis revealed that age above 65 years, Diabetes Mellitus,
Hypertension, congestive heart failure, and abnormal baseline LFTs were
all were independently associated with the composite endpoint.
Multivariate analysis revealed that abnormal baseline LFTs (OR 6, 95%
CI 2.0 – 18.4) was the strongest predictor of meeting the composite
endpoint followed by diabetes mellitus (OR 4.5, 95% CI 1.3 – 14.8) and
congestive heart failure (OR 3.9, 95% CI 1.2 – 12.5).