How Close Is a Coronavirus Vaccine?
Engineered virus might be able to block coronavirus infections. Mouse study shows many responses. A new intranasal vaccine using an RNA virus for gene delivery protects against fatal MERS coronavirus infections in mice. The mice were genetically engineered .All the mice that received the vaccine survived MERS, while the mice that had not received the vaccine did not. The researchers are now applying the same strategy to develop a vaccine for SARS-CoV-2, the virus that causes COVID-19, which has infected more than a million people worldwide, signified the challenge for finding an effective vaccine against the coronavirus that causes COVID-19,left only the race against time, McCray said once, that, one hundred percent of the population if not exposed by the virus, that does not mean that there will be no people or more people will not be infected when it comes again,”. It is very difficult to say against lasting immunity against SARS-CoV-2 infection, so it’s important to think about vaccine to protect the population. “The American Society for Microbiology is one of the largest professional societies, dedicated to microbiology, life sciences and is composed of 30,000 scientists and health practitioners. [22 ], emphasize also for corona-vaccine. Several pharmaceutical industries are recently involved to develop corona vaccine. “Moderna” set a drug industry with mRNA-1273, a vaccine candidate identified recently after the novel coronavirus was sequenced. “National Institutes of Health “USA describes mRNA-1273 could be used to develop monoclonal antibody and the same could be used safe to prevent corona. “Moderna” took the responsibility to use mRNA. “Food and Drug Administration”, USA approved the use of mRNA medicines. “Germany’s Biotech” is working on an mRNA vaccine for the novel coronavirus, mRNA to spur the production of protective antibodies. “Shanghai’s Fosun Pharma” jointly moving with Biotech’s vaccine in China. “Pfizer” participated in the program to co-develop the vaccine in the rest of the world. “Takeda” is approaching preclinical treatment, using blood of people who have already been infected by the coronavirus. Spanish Flu pandemic of 1918, “Takeda” emphasizes, that plasma treatment could take responsible phase in treatment corona patients. According to the company, the therapy could be available to patients in 12 to 18 months. “Johnson & Johnson”, applied vaccines against Ebola and Zika virus. The company is in the early days of developing a vaccine against corona. Human trials could begin by November. At the same time, J&J is working with the federal Biomedical Advanced Research and development authority on potential treatments for patients who are already infected, a process that includes investigating whether any of its older medicines might work against the corona virus. “Glaxo-Smith-Kline’, one of the world’s largest vaccine manufacturers, is lending its technology to a chinese biotech firm at work on a coronavirus vaccine. Stanford University, Schools of Engineering & MedicineBottom of Form
, approaching and took the initiative on CRISPR(clustered regularly interspaced short palindromic repeats).CAS(CRISPR associated protein)-9 technology.Crisper-cas-9 will work as transposons and will detect the presence of coronavirus, protein to repaire.The Stanley Qi Lab is exploring ways that Crispr technology can be used to fight the coronavirus pandemic. Their latest results are one piece of a larger puzzle. March 18, 2020.Stanley Qi, a pioneer in Crispr technology tools.  However, one challenge is still remain, how long we have to wait, and whether: ”Could Crispr Be Humanity’s Next Virus Killer?” , the” Development of CRISPR as a prophylactic strategy to combat Coronavirus and Influenza. Different approaches have been discussed, [25], on s pike protein by CRISPR-CAS-9, RNA based spike protein modifications. Scientists are developing hundreds of coronavirus vaccines using a range of techniques, some of which are well-established and some of which have never been approved for medical use before. Whole-Virus vaccines inactivated and live attenuated vaccines, genetic vaccines are being partially used against coronavirus, using genetic code of virus and human hosts. RNA vaccines with viral vector vaccines. Vaccines using adenovirus or other viruses protein-based vaccines, vaccines that use against coronavirus. Protein or a protein fragment, recombinant vaccines, yeast or other cells can be engineered to carry a virus gene and to generate viral proteins, which are then harvested and put into a vaccine, a coronavirus vaccine of this design would contain whole spike proteins or small pieces of the protein. This category includes some vaccines for shingles and hepatitis B. However the author’s IS-Tn-Tn recombined by spike protein cloned plasmid, transformed into Escherichia colik-12 and their isolated surface hybrid recombined protein, applied against corona, has not been discussed till date. As the per the devoted, science and life sciences matured intuition, the author on microbes, yeas long day and night keen observations in experiment interest shown in academic maturity emphasized, that “IS-Tn-IS” hybrid, spike protein DNA recombined hybrid GE (Genetically Engineered ) E.coli K-12 hybrid protein, applied orally perhaps would show the relief and safety of mankind.