Fig11(a-c) ) (b)(c)
Graphic adapted by N carry /Science, Fig .11(a-c), describe the data for total confirmed COVOID-19 patients globally. Pink VioletDark Violet, Dark -Violate represents the most affected area of USA, Europe.Fig 11(b) shows the future perspective of DNA Vaccine, injecting to muscle and their immunological response to MHC, CD8, CF4 and B-Cell.Fig.11(c) represents, the conceptual propagation of “Herd-Immunity ”. Herd immunity is still remain as speculation since the rapid mutation of corona. DNA vaccine model would also be difficult, since the mobility of corona is spontaneous. Based on the above information the author has taken some initiative to discuss the present crisis of corona, would be different and where the spontaneous mutations are occurring. The mischievous/ unknown spontaneous killing nature of SARS COV- 2 virus, n-COVID-19 infections can only be prevented by vaccinations, where monoclonality in humoral and cytotoxicity of antibodies are concerned and should be spontaneous, and memory based. One proposal IS mediated antibody development could be feasible as proposed by the author It is to be mentioned that humoral and cytotoxic natures of vaccinations are concerned. Since Corona is pandemic. Humoral types would be used for the future generation and cytotoxic types would be used for present situation, for those, who are infected and are being separated as a-symptomatic, co-morbid class., the Corona pandemic or endemic infections cover many and vast knowledge of information and understanding. Starting from medical and biological sciences, corona treatment needs also good understand of physics and engineering, the movements of molecules and fluids in and around respiratory system. The concept of microfluidics, the molecular transport, the concept of pressure and temperature driven molecular transport, all would be considered to consider the design concept of cytotoxic vaccine of corona. In lung, alveoli, where the adherence of virus is predominant, the adherence mechanisms of corona spikes and its protection by humoral antibodies would perhaps be the ultimate vaccinations of corona. On the surface of lung cell spike proteins of corona manage the biochemical functions of ACE_I and II in cell receptors of lung cell damage. It is also not possible to design vaccine, when virus is already in entry, because virus corona expresses many antigenic variations inside the body. The design of vaccine represents the molecule responsible for humoral immune response must be well known. However, the author believes, that AAIR (Anti-adherent Immune Response) against corona could one of the solutions. Cytotoxic immunity does not allow to prevent the entry of corona virus inside the lung cell and or any organ specific epithelial cells it will only prevent the growth of corona. Humoral antibody in the human body as AAIR would be appropriate at present to design vaccine with IS sequence to prevent corona infection.[1, 4-7, 10-,20]. Till date no vaccine has been developed [21-25 ] . Corona was known to the scientists and medical practitioner since 1978[10], page 619 , but its epidemic and pandemic nature were not discussed. So it might be considered to realize, that corona similarsers-cov-2 virus is continuously mutated towards. MERS, influenza, H1N1, Swine or Chicken flues and returned to returned back to present corona stage and in between transformed to insect vector-borne diseases, like mosquito as Dengue and Ebola by some other vectors.IS-Tn-IS might have some reason to search and to establish polio like oral vaccine, ultimately to win from all such mischievous, viral culprits and to save the mankind. So long the mechanism of infection of corona is not properly understood, it would be difficult to design corona vaccine. The basic objective of the scientists would be to protect the entry of corona virus, i.e. to design AAIR through IS mediated DNA RNA manipulation of corona virus would be one way.