How Close Is a Coronavirus Vaccine?
Engineered virus might be able to block coronavirus infections. Mouse
study shows many responses. A new intranasal vaccine using an RNA virus
for gene delivery protects against fatal MERS coronavirus infections in
mice. The mice were genetically engineered .All the mice that received
the vaccine survived MERS, while the mice that had not received the
vaccine did not. The researchers are now applying the same strategy to
develop a vaccine for SARS-CoV-2, the virus that causes COVID-19, which
has infected more than a million people worldwide, signified the
challenge for finding an effective vaccine against the coronavirus that
causes COVID-19,left only the race against time, McCray said once, that,
one hundred percent of the population if not exposed by the virus, that
does not mean that there will be no people or more people will not be
infected when it comes again,”. It is very difficult to say against
lasting immunity against SARS-CoV-2 infection, so it’s important to
think about vaccine to protect the population. “The American Society
for Microbiology is one of the largest professional societies, dedicated
to microbiology, life sciences and is composed of 30,000 scientists and
health practitioners. [22 ], emphasize also for
corona-vaccine. Several pharmaceutical industries are recently involved
to develop corona vaccine. “Moderna” set a drug industry with
mRNA-1273, a vaccine candidate identified recently after the novel
coronavirus was sequenced. “National Institutes of Health “USA
describes mRNA-1273 could be used to develop monoclonal antibody and the
same could be used safe to prevent corona. “Moderna” took the
responsibility to use mRNA. “Food and Drug Administration”, USA
approved the use of mRNA medicines. “Germany’s Biotech” is working on
an mRNA vaccine for the novel coronavirus, mRNA to spur the production
of protective antibodies. “Shanghai’s Fosun Pharma” jointly moving
with Biotech’s vaccine in China. “Pfizer” participated in the program
to co-develop the vaccine in the rest of the world. “Takeda” is
approaching preclinical treatment, using blood of people who have
already been infected by the coronavirus. Spanish Flu pandemic of 1918,
“Takeda” emphasizes, that plasma treatment could take responsible
phase in treatment corona patients. According to the company, the
therapy could be available to patients in 12 to 18 months. “Johnson &
Johnson”, applied vaccines against Ebola and Zika virus. The company is
in the early days of developing a vaccine against corona. Human trials
could begin by November. At the same time, J&J is working with the
federal Biomedical Advanced Research and development authority on
potential treatments for patients who are already infected, a process
that includes investigating whether any of its older medicines might
work against the corona virus. “Glaxo-Smith-Kline’, one of the world’s
largest vaccine manufacturers, is lending its technology to a chinese
biotech firm at work on a coronavirus vaccine. Stanford University,
Schools of Engineering & MedicineBottom of Form
, approaching and took the initiative on CRISPR(clustered regularly
interspaced short palindromic repeats).CAS(CRISPR associated protein)-9
technology.Crisper-cas-9 will work as transposons and will detect the
presence of coronavirus, protein to repaire.The Stanley Qi Lab is
exploring ways that Crispr technology can be used to fight the
coronavirus pandemic. Their latest results are one piece of a larger
puzzle. March 18, 2020.Stanley Qi, a pioneer in Crispr technology
tools. However, one challenge is still remain, how long we have to
wait, and whether: ”Could Crispr Be Humanity’s Next Virus
Killer?” , the” Development of CRISPR as a prophylactic strategy to
combat Coronavirus and Influenza. Different approaches have been
discussed, [25], on s pike protein by CRISPR-CAS-9, RNA
based spike protein modifications. Scientists are developing hundreds of
coronavirus vaccines using a range of techniques, some of which are
well-established and some of which have never been approved for medical
use before. Whole-Virus vaccines inactivated and live attenuated
vaccines, genetic vaccines are being partially used against coronavirus,
using genetic code of virus and human hosts. RNA vaccines with viral
vector vaccines. Vaccines using adenovirus or other viruses
protein-based vaccines, vaccines that use against coronavirus. Protein
or a protein fragment, recombinant vaccines, yeast or other cells can be
engineered to carry a virus gene and to generate viral proteins, which
are then harvested and put into a vaccine, a coronavirus vaccine of this
design would contain whole spike proteins or small pieces of the
protein. This category includes some vaccines for shingles and hepatitis
B. However the author’s IS-Tn-Tn recombined by spike protein cloned
plasmid, transformed into Escherichia colik-12 and their isolated
surface hybrid recombined protein, applied against corona, has not been
discussed till date. As the per the devoted, science and life sciences
matured intuition, the author on microbes, yeas long day and night keen
observations in experiment interest shown in academic maturity
emphasized, that “IS-Tn-IS” hybrid, spike protein DNA recombined
hybrid GE (Genetically Engineered ) E.coli K-12 hybrid protein,
applied orally perhaps would show the relief and safety of mankind.