Classification and Antigenic Type:
The corona viruses were originally grouped into the family Corona, is known as crown constituted by glycoprotein-studded envelope,Fig.2-4. Most human corona virus fall into one of two groups of 229E and OC43-like. These differ in both antigenic determinants and culturing requirements: 229E-like corona viruses can usually be isolated in human embryonic fibroblast cultures; OC43-like viruses can be isolated from suckling mouse brain. There is little antigenic cross-reaction between these two types found, and cause independent epidemics. It is thought that human coronaviruses enter cells, predominantly, by specific receptors like amino peptidase-N and sialic acid-containing receptors.229E and OC43 respectively antigenic variants during infection enter the host cell and release their genome RNA to transcribe and to translate. (Messenger) mRNAs of the host lung cells and their 3′ ends. 5′ ends are used for translating coat protein. There are 7 mRNAs are involved in such envelop coat proteins development and are assembled at the cell membrane. The genomic RNA is involved to develop virus particles and to get released by budding from internal cell membrane ruptures. Studies in both organ cultures and human cells, it is observed that infected cells become vacuolated. Cell damage triggers the production of inflammatory mediators, which increase nasal secretion, local inflammation and swelling to stimulate sneezing, obstruct the airway, and raise the temperature. The growth of several opportunistic, Bacillaceae, Coccaceae, Chlamydomonas, of microbial family, influence the increasing inflammation, symbiotically survives with corona to damage mucocilliary activity of the respiratory tract and lung, and to bring the patients to death,[18-19]. Interferon(IF) can protect against infective stage, but its expression in human immune system with MHC( Major Histocompatibility Complex- HLA ( Human Link Antigen) and IL( Interleukin10(IL10), is not well defined in case of corona. Because coronavirus infections are common, many individuals have specific antibodies in their nasal secretions, and these antibodies can protect against infection. Most of these antibodies are directed against the surface projections and neutralize the infectivity of the virus. Cell-mediated immunity and allergy have not been studied vast to confirm the mode of corona allergic inflammations. The epidemiology of coronavirus colds is not well defined and studied. Hard Immunity concept is an alternative infection movement, pass through communities, and occurs during winter months in families, schools, and locality to block corona infection. [11-15].