Fig.10(a) (b) (c) (d)(e)
Jumping genes, Fig.10(a-e), [ 1, 4-7,8,9-16] , (a) shows
the structure of one Tn, flanked by IS elements Left and Right end to Tn
palindrome, (b) repeats are identified by the sequences of IS elements,
repeat and inverted repeats of IS (c) Recombination and sequence
multiplications of IS-Tn-IS is reproduced in plasmid and chromosome
hybrid combination ( d) Animated concept of jumping sequence of DNS
sequence, (e) Historical discovery of Tn by Barbara Mc Clintock.
IS based Tn (Transposons) are involved in viral evolution, mutation,
camouflaging infective nature of SARS COV-2 virus, corona[9-16]. Jumping-genes as retro transposons [8]hijacks special cells called nurse cells, produce invasive nature of DNA
driving evolution, and causing disease. Almost half of our DNA sequences
are made up of jumping genes, known as transposons. They jump around the
genome in developing sperm and egg cells and are important in cellular
evolution [4-7] and cause new mutations that lead to
diseases. Remarkably little is known about when and where their
movements occur in developing reproductive cells, the key process that
ensures their propagation in future generations but can lead to genetic
disorders for the hosts. Animals have developed a powerful system to
suppress jumping gene activity that uses small, non-coding RNAs called
pi RNAs (Piwi-interacting RNA (pi RNA) is the largest class of
small non-coding RNA molecules expressed in animal cells, through piwi
-subfamily Argonaute proteins. which recognize jumping genes and
suppress their activity. Occasionally, jumping genes could mobilize
virus infection, propagated from Wuhan, China, to all over the world
without any variations of RNA. Measurement of antibodies to SARS-CoV-2
will improve disease management if used correctly. In late 2019, China
reported a cluster of atypical pneumonia cases. The causative agent was
identified as a new beta coronavirus, called severe acute respiratory
syndrome. The virus rapidly spread across the globe and caused a
pandemic. Sequencing and IS hybridization of the viral genome allows the
development of nucleic acid–in hybrid and wild types, that could have
been widely used for the diagnosis of acute (current) SARS-CoV-2
infections [19].