Fig.1. Fig.2 Fig.3 Fig.4 Fig.5
Fig.1 describe, the possible mechanism the formation of virus
particles through NA( Nucleic Acid) fragments, Fig.2, and 3, SEM view of
Corona, and H1N1 virus , Fig. 4 shows the molecular structure of
SARS-COV-2 RNA-virus, Fig.5 shows the SEM view of Wuhan corona
clustered .
SEM derived images of Covid-19, SARS-Cov-2, and H1N1 virus shows the
similarities of surface antigen, spike protein, where Wuhan corona show
no spikes. The spontaneous reaction of viruses, specially corona can be
speculated, that due to ss RNA, it will immediately transcribed to form
capsid protein and for the multiplications of virus particles in lung
cells, using r-RNA of the infected lung cells, after penetration, virus
uses 3′ end of ss mRNA and floating r-RNA of the host lung cells to
generate envelope. Envelop of Corona is made by glycoprotein as matrix
protein. It encapsulates ss RNA of the replicating ssRNA of the virus,
after fusions of coat- glycoprotein with lung cell surface membrane
attachments OC43 haemagglutinin type virions are released from host
cell, as reported, ruptured cell membrane. New virions of corona,
transmit the infection via airborne droplets to the healthy recipients.
Virus replicates/multiply locally in cells of the ciliated epithelium,
causing cell damage and inflammation. The appearance of antibody in
serum and nasal secretions follow the infection and increase immunity
peaks in the winter as local epidemics and could last for a few weeks or
months. The same serotype may return to the same locality after several
years. The virus is difficult to isolate. Nucleic acid hybridization
tests (including PCR) are now being introduced as control treatment of
common colds and within a-symptomatic patients. No vaccines or specific
drugs are available till date. Only vaccine with IS element approach
could be an alternative solution to face the present crisis, if at all
be successful, [7-10]. Coronaviruses are found in avian and
mammalian species. They resemble same each other in morphology and in
chemical structure. Even coronaviruses of humans and cattle are found
same in their antigens, there is no evidence till date that human
coronaviruses can be transmitted from cattle and from animals. In
animals, coronaviruses invade many different tissues and cause a variety
of diseases, as respiratory infections, i.e. common colds. On rare
occasions, gastrointestinal coronavirus infection has been recorded
among children, but these enteric viruses are not well defined. After an
incubation period of about 3 days, corona virus can cause the symptoms
of a common cold, including nasal obstruction, sneezing, runny nose, and
secretions. Presence of corona in multiple sclerosis are also not well
defined including their infections, [11-17]. Wuhan corona
SEM picture, Fig.5, represents the similar 026: EPEC bacterial
cluster, as they were reproduced by the author during 1983. The
curiosity remains, that whether they have the similar adhering and
invasive, colonizing nature, as corona on lung epithelial cells, as in
026: EPEC, inspired the author to recapitulate, theoretically the
colonial invasive nature of corona as in 026: EPEC. The question is
whether, corona has procured similar gene (haemagglutine) of adhering
and invasions as in 026: EPEC.