Fig11(a-c) )
(b)(c)
Graphic adapted by N carry /Science, Fig .11(a-c), describe the
data for total confirmed COVOID-19 patients globally. Pink VioletDark
Violet, Dark -Violate represents the most affected area of USA, Europe.Fig 11(b) shows the future perspective of DNA Vaccine,
injecting to muscle and their immunological response to MHC, CD8, CF4
and B-Cell.Fig.11(c) represents, the conceptual propagation of
“Herd-Immunity ”. Herd immunity is still remain as speculation
since the rapid mutation of corona. DNA vaccine model would also be
difficult, since the mobility of corona is spontaneous. Based on the
above information the author has taken some initiative to discuss the
present crisis of corona, would be different and where the spontaneous
mutations are occurring. The mischievous/ unknown spontaneous killing
nature of SARS COV- 2 virus, n-COVID-19 infections can only be prevented
by vaccinations, where monoclonality in humoral and cytotoxicity of
antibodies are concerned and should be spontaneous, and memory based.
One proposal IS mediated antibody development could be feasible as
proposed by the author It is to be mentioned that humoral and cytotoxic
natures of vaccinations are concerned. Since Corona is pandemic. Humoral
types would be used for the future generation and cytotoxic types would
be used for present situation, for those, who are infected and are being
separated as a-symptomatic, co-morbid class., the Corona pandemic or
endemic infections cover many and vast knowledge of information and
understanding. Starting from medical and biological sciences, corona
treatment needs also good understand of physics and engineering, the
movements of molecules and fluids in and around respiratory system. The
concept of microfluidics, the molecular transport, the concept of
pressure and temperature driven molecular transport, all would be
considered to consider the design concept of cytotoxic vaccine of
corona. In lung, alveoli, where the adherence of virus is predominant,
the adherence mechanisms of corona spikes and its protection by humoral
antibodies would perhaps be the ultimate vaccinations of corona. On the
surface of lung cell spike proteins of corona manage the biochemical
functions of ACE_I and II in cell receptors of lung cell damage. It is
also not possible to design vaccine, when virus is already in entry,
because virus corona expresses many antigenic variations inside the
body. The design of vaccine represents the molecule responsible for
humoral immune response must be well known. However, the author
believes, that AAIR (Anti-adherent Immune Response) against corona could
one of the solutions. Cytotoxic immunity does not allow to prevent the
entry of corona virus inside the lung cell and or any organ specific
epithelial cells it will only prevent the growth of corona. Humoral
antibody in the human body as AAIR would be appropriate at present to
design vaccine with IS sequence to prevent corona
infection.[1, 4-7, 10-,20]. Till date no vaccine has been
developed [21-25 ] . Corona was known to the scientists and
medical practitioner since 1978[10], page 619 , but its
epidemic and pandemic nature were not discussed. So it might be
considered to realize, that corona similarsers-cov-2 virus is
continuously mutated towards. MERS, influenza, H1N1, Swine or Chicken
flues and returned to returned back to present corona stage and in
between transformed to insect vector-borne diseases, like mosquito as
Dengue and Ebola by some other vectors.IS-Tn-IS might have some reason
to search and to establish polio like oral vaccine, ultimately to win
from all such mischievous, viral culprits and to save the mankind. So
long the mechanism of infection of corona is not properly understood, it
would be difficult to design corona vaccine. The basic objective of the
scientists would be to protect the entry of corona virus, i.e. to design
AAIR through IS mediated DNA RNA manipulation of corona virus would be
one way.