Statistical analysis
Statistical analyses were conducted using SPSS software (version 22.0,
SPSS Inc., Chicago, IL, USA). The data are expressed as medians and
ranges or as frequencies (percentages). All tests were two tailed, andP <0.05 was considered significant. The values of
continuous variables in the expressors and non-expressors were compared
using the Mann-Whitney U test, and the Wilcoxon test was used to
compare the value of continuous variables within the same group. The
distributions of categorical variables were compared with the Fisher
exact test. The effect of CYP3A5 polymorphism on changes in
tacrolimus exposure after the conversion to once-daily formulation was
tested during the analysis of covariance (ANCOVA).