Study design
This prospective, multicenter, open-label, exposure-variable study was carried out at the Samsung Medical Center (Seoul, Korea), Seoul National University Hospital (Seoul, Korea), and Yangsan Pusan National University Hospital (Yangsan, Busan) between August 2016 and June 2018. The study was carried out in accordance with the Declaration of Helsinki and was registered at ClinicalTrials.gov (NCT 02882113). The protocol of the study was approved by the Institutional Review Boards at the Samsung Medical Center (IRB No. 2015-11-140), Seoul National University Hospital (IRB No. H-1510-097-712), and Yangsan Pusan National University Hospital (IRB No. 04-2015-038). All participants provided written informed consent to participate in the study.