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Multi-Physics Modeling of Doxorubicin Binding to Ion-Exchange Resin in Blood Filtration Devices
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  • Nazanin Maani,
  • Nitash Balsara,
  • Steven Hetts,
  • Vitaliy Rayz
Nazanin Maani
Purdue University
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Nitash Balsara
University of California, Berkeley
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Steven Hetts
University of California San Francisco
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Vitaliy Rayz
Purdue University
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Peer review status:IN REVISION

18 Jun 2020Submitted to AIChE Journal
18 Jun 2020Assigned to Editor
18 Jun 2020Submission Checks Completed
22 Jun 2020Reviewer(s) Assigned
05 Aug 2020Editorial Decision: Revise Major

Abstract

A group of drugs used in Intra-Arterial Chemotherapy (IAC) have intrinsic ionic properties, which can be used for filtering excessive drugs from blood in order to reduce systemic toxicity. The ion-exchange mechanism is utilized in an endovascular Chemofilter device which can be deployed during the IAC for capturing ionic drugs after they have had their effect on the tumor. In this study, the concentrated solution theory is used to account for the effect of electrochemical forces on the drug transport and adsorption by introducing an effective diffusion coefficient in the advection-diffusion-reaction equation. Consequently, a multi-physics model coupling hemodynamic and electrochemical forces is developed and applied to simulations of the transport and binding of Doxorubicin in the Chemofilter device. A comparison of drug adsorption predicted by the computations to that measured in animal studies demonstrated the benefits of using concentrated solution theory over the Nernst-Plank relations for modeling drug binding.