Mol. wt. 404 Da, 1 nmol = 404 ng
metabolism CYP2D6, CYP1A2 (minor) 96
psychiatric dose 4 to 32 mg/d 96
metabolites
Perphenazine sulfoxide, Dealkyl perphenazine
96
half-life ~ 10 hours, blood 96, 97
common blood level
1 to 10 nmol/L 1.5 ng/ml perphenazine = 3.7 nmol/L 0.8 ng/ml perphenazine sulfoxide, 2.0 ng/ml dealkyl perphenazine
98, 99, 103
Side effects >5% day sedation at > 8 mg/day 102
Side effects 1-5% akathisia, hyperprolactinemia, hypotension, sexual dysfunction, mainly at >8 mg/d 102
Side effects <1% neuroleptic malignant syndrome 89
psychiatric use antipsychotic, antidepressant augmentation, agitation states 102
other uses anti-nausea, antipruritic, anti-vertigo 84,100, 101