KEY RESULTS
Smokers, versus non-smokers, had significantly lower levels of lung CYP2A13, CYP2A6 and CYP2A7 (and increased CYP1A2) mRNA in both GEO datasets. Nicotine treatment, at both doses, significantly decreased AGM lung CYP2A protein. Ethanol self-administration had no effect on AGM lung CYP2A protein, and there was no interaction between ethanol and nicotine.