Methods
“Melina” an 11-year old girl infected with SARS-CoV-2 was
prospectively followed up by her family doctor and interviews were
conducted by a researcher physician. Family members were also
semi-qualitatively interviewed, including clinical manifestations,
epidemiological characteristics, and laboratory tests.
Naso-oropharyngeal swab tests were used to detect SARS-CoV-2 via
real-time PCR cobas, Roche Company. In addition to the COVID-19 pathogen
(SARS-CoV-2), this test detects SARS- CoV-1 and other sarbecoviruses. No
cross reactivity with common respiratory corona viruses (CoV-NL63, 229E,
HKU, OC43 or MERS-CoV). Melina drew a picture of herself in the corona
situation. Six weeks after Melina’s positive initial testing, her
pediatrician carried out serum antibody tests in the family using the
Acro 2019-nCoV IgG/IgM Rapid Test. IgG relative sensitivity: 100% (95%
Confidence Interval (CI): 86.0%-100%), relative specificity: 98.0%
(95% CI: 89.4%-99.9%); IgM relative sensitivity: 85.0% (95% CI:
62.1%-96.8%), relative Specificity: 96.0% (95% CI: 86.3%-99.5%).