Legends
Figure 1. (A) A retroauricular subcutaneous nodule. (B) Enhanced computed tomograohy image showing peri-pleural nodular shadows mainly in the right lung field. (C) Multiple low-density areas in the liver. (D) Multiple low-density areas of approximately 1.0 cm in diameter in the right kidney. (E) Enhanced magnetic resonance images of the lesions of the medulla and cerebellar hemisphere and (F) the massive tumour in the spinal cord from the level of the atlas to the upper thoracic spine before the initiation of alectinib therapy. (G) Complete regression of the lesions of the medulla and cerebellum 2 months after the initiation of alectinib therapy. (H) The lesions of the spinal cord also regressed.
Figure 2. (A) Histological examination (HE; haematoxylin-eosin) result of the biopsy specimen from the cutaneous lesion. (B) The spindle cells with circular unequal nucleus and light cytoplasm. (C) Increased tumor cells between the dermal collagen fibres. (D) The spindle cells showing positivity for ALK1 antibody and (E, F) positivity for ALK D5F3 by immunohistological tests.