Legends
Figure 1. (A) A retroauricular subcutaneous nodule. (B)
Enhanced computed tomograohy image showing peri-pleural nodular shadows
mainly in the right lung field. (C) Multiple low-density areas in the
liver. (D) Multiple low-density areas of approximately 1.0 cm in
diameter in the right kidney. (E) Enhanced magnetic resonance images of
the lesions of the medulla and cerebellar hemisphere and (F) the massive
tumour in the spinal cord from the level of the atlas to the upper
thoracic spine before the initiation of alectinib therapy. (G) Complete
regression of the lesions of the medulla and cerebellum 2 months after
the initiation of alectinib therapy. (H) The lesions of the spinal cord
also regressed.
Figure 2. (A) Histological examination (HE; haematoxylin-eosin)
result of the biopsy specimen from the cutaneous lesion. (B) The spindle
cells with circular unequal nucleus and light cytoplasm. (C) Increased
tumor cells between the dermal collagen fibres. (D) The spindle cells
showing positivity for ALK1 antibody and (E, F) positivity for ALK D5F3
by immunohistological tests.