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Rothia mucilaginosa, an important cause of invasive disease in children with leukemia: Report of 2 cases and review of the literature
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  • Valentina Gutierrez,
  • Carolina Cerda,
  • Alex Alcantara,
  • Ximena Claverie
Valentina Gutierrez
Complejo Asistencial Doctor Sotero del Rio
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Carolina Cerda
Pontificia Universidad Catolica de Chile Facultad de Medicina
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Alex Alcantara
Complejo Asistencial Doctor Sotero del Rio
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Ximena Claverie
Complejo Asistencial Doctor Sotero del Rio
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Abstract

Rothia mucilaginosa is an opportunistic agent detected in the upper respiratory tract and oral cavity in humans. Immunocompromised hosts have more risk to develop severe infections. We present a short review and two clinical cases of Rothia mucilaginosa bloodstream infection in children with leukemia, one of them with endocarditis. Both were completely recovered. Predisposing factors for Rothia mucilaginosa infection include profound and prolonged neutropenia, use of central venous catheter, mucositis and high dose steroid. It is important to consider this bacterium as an emerging causative agent of severe infection in immunocompromised patients, especially in the presence of the mentioned factors.