Figure legends
Figure 1. Effect of frequency on impulse oscillometry
resistance in children with different levels of Σ4HMWP
metabolites (A) and Σ3LMWP metabolites (B). Lines were
determined by locally weighted smoothing functions and shaded areas
indicate 95% confidence intervals. The level of Σ4HMWP
metabolites (A) was significantly associated with Rrs1, Rrs2, and Rrs3
after adjusting for height, gender, BMI z- score, aeroallergen
sensitization, secondary smoking, and vitamin D level. The level of
Σ3LMWP metabolites (B) was significantly associated with
Rrs1, Rrs2, Rrs3, Rrs5, Rrs10, and Rrs15 after adjusting for these same
factors. LMHP, low molecular weight phthalate; HMWP, high molecular
weight phthalate; Rrs, respiratory system resistance.
Figure 2. Mediation model used to investigate the effect of
serum periostin on the relationship between LMWP metabolites and lung
dysfunction (Rrs5). The level of Σ3LMWP metabolites was
significantly and directly associated with Rrs5 (β: 0.084, 95% CI:
0.005 to 0.14, P = 0.04), and periostin (β: 0.013, 95% CI: 0.002
to 0.030, P < 0.001) mediated 13.8% of this effect
(95% CI: 10.7 to 77.0, P < 0.001). The analysis
adjusted for height, gender, BMI z- score, aeroallergen
sensitization, secondary smoking, and vitamin D level. LMWP, low
molecular weight phthalate; Rrs5, respiratory system resistance at 5 Hz.
Supplementary Figure E1. Concentrations (μg/g creatinine) of
LMWP metabolites (top) and HMWP metabolites (bottom) in 487 urine
samples. MEHHP, mono-(2-ethyl-5-hydroxyhexyl) phthalate; MCPP,
mono-(3-carboxypropyl) phthalate; MECPP, mono-(2-ethyl-5-carboxypentyl)
phthalate; MiBP, mono-(iso-butyl) phthalate; MEOHP,
mono-(2-ethyl-5-oxohexyl) phthalate; MNP, mono-isononyl phthalate;
MBzP), mono-benzyl phthalate. Horizontal lines separate the different
quartiles.