Interventions:
Case 1 received azithromycin and hydroxychloroquine, intravenous
hydrocortisone, colchicine, and zinc. Pericardiocentesis and pericardial
window were performed on hospital days 1 and 7, respectively. He
received therapeutic anti-coagulation with enoxaparin for the first 7
days due to elevated D-dimer level, which was transitioned to deep
venous thrombosis (DVT) prophylactic dose enoxaparin for the following 9
days after development of sanguineous pericardial tamponade.
Case 2 received intravenous hydrocortisone, hydroxychloroquine and
azithromycin, and required pericardial window on hospital day 1.
Case 3 received azithromycin, hydroxychloroquine, and tocilizumab twice
(before and after ECMO). The patient received ceftriaxone and
doxycycline initially and was subsequently transitioned to cefepime. He
required ECMO and pericardiocentesis on hospital days 5 and 7,
respectively, as well as mechanical ventilation for 6 days. DVT
prophylactic dose of unfractionated heparin was administered for the
first 5 days of hospitalization, followed by therapeutic dose for the
next 4 days.