Prebiotics
In adult asthmatic patients, a randomised, double-blind,
placebo-controlled, cross-over design study examined the effects of 3
weeks supplementation with 5.5 g/day Bimuno-galactooligosaccharide
(B-GOS). Supplementation with this prebiotic reduced the severity of
hyperpnoea-induced bronchoconstriction (HIB, a surrogate for
exercise-induced bronchoconstriction), as well as concomitant markers of
airway inflammation.50 Recipients displayed a 40%
improvement in FEV1 decline after EVH, and B-GOS supplementation reduced
baseline concentrations of CCL17, CRP and TNF-α as well as EVH-induced
increase in TNF-α.