Gene enrichment analysis
In order to find out why the risk score can predict the survival of
patients with COAD, the samples were grouped according to the median
risk score, namely high-risk group and low-risk group. Implement GSEA in
the high-risk and low-risk groups to investigate the ways of change. We
identified the KEGG enrichment pathway of model genes in TCGA-COAD. GSEA
analysis showed that the altered genes were observed to be enriched in
several common pathways. Among the 178 genomes of the high-risk
phenotype group, 130 genomes were up-regulated, and 62 genomes were
significant at FDR <25%. Most enrichment pathways are
concentrated in metabolic pathways, such as arginine and proline
metabolism, fructose and mannose metabolism, galactose metabolism, and
nicotinate and nicotinamide metabolism. The results also include some
well-known cancer-related pathways, such as antigen processing and
presentation, basic transcription factors, endometrial cancer,
glycolytic gluconeogenesis, erbb signaling pathway, and
glycosylphosphatidylinositol gpi anchor biosynthesis. It shows some
representative pathways in figure 4. The relevant parameters of the
channel are listed in Table 2. The results further illustrate the role
of metabolic mechanisms in COAD.