C. rodentium-induced colitis
Jiang et al. (2016) established the C. rodentium -induced colitis model approach [15] that was used the present study. The mice in the CR and TS+CR groups were rapidly administered 2×109 CFU/mL C. rodentium 24 h after fasting, while the mice in the control and TS groups were administered the same amount of PBS. The colitis mouse model elicited a Th1-type immune response, which was similar to that observed in human CD. Inflammation was assessed based on bellowed parameters, including clinical disease activity and the macroscopic and microscopic inflammation scores in the colon tissue. The grading was performed by three investigators blinded for the treatment of the mice.