Colon pathological changes
To further evaluate the protective effects of T. spiralis inC. rodentium infection, on day 14 after the start of modelling,
distal colon samples were collected and evaluated by H&E staining. As
expected, no pathogenic changes were observed in either the control
group or TS groups (Fig. 4A&C), whereas the CR group exhibited typical
pathological changes, including colonic epithelial cells proliferation,
intestinal wall oedema, large amounts of inflammatory cell infiltration
in the lamina propria, elongated crypts and the reduction or
disappearance goblet cells (Fig. 4B). In the TS+CR group, the
hyperplasia of colonic epithelial tissue disappeared, the lesions were
limited to the mucosa, and the lamina propria of the mucosa was
scattered with inflammatory cells ((Fig. 4D).