Acknowledgments
We are grateful for the C. rodentium provided by Dr. Haining Shi Harvard Medical School, Boston, MA, USA. This work was supported by the National Key Research and Development Program of China (2017YFD0500400, 2017YFD0501200, 2017YFD0501000), the National Natural Science Foundation of China (31672528, 31941018) and Science and Technology Development Program of Jilin Province (20180201040NY, 20190301042NY).