Experimental grouping
The experimental mice were randomly divided into four groups, with more than nine mice in each group: the control group (PBS), the T. spiralis -infected group (TS), the C. rodentium -induced colitis model group (CR), and the T. spiralis -pre-infected C. rodentium -induced colitis group (TS+CR). At the beginning of the experiment, each mouse in the TS and TS+CR groups was orally infected with 400 individual T. spiralis muscle larvae. After 21 days of infection, the control and TS groups were administered PBS, and the CR and TS+CR groups were administered 2×109 CFU/mLC. rodentium . Subsequently, the faeces of mice in the CR and TS+CR groups were collected every day from days 1 to 14 post C. rodentium infection, the colony count of faeces was determined, and the number of C. rodentium per gram of faeces (CFU/g) was calculated. The mice were sacrificed under euthanasia on days 7 and 14, and the weights of the mice in the four groups was determined daily.