IGA 3-4 (severe papulo-pustular or conglobate acne) |
Isotretinoin or
tetracyclines systemic treatment within last 12 months |
Partial/absent response to previous acne treatments |
Topical retinoid
treatment within last 6 months |
Ineligibility to standard dose of retinoids |
Use of
photosensitivity-inducing drugs |
Refusing standard dosage therapy with isotretinoin due to risk of
collateral effects |
Use of corticosteroids within last 6
months |
Anamnestic discontinuation of standard dosage therapy with systemic
retinoids due to unsustainable side-effects |
Pregnancy or
breast-feeding |
No clearance with combined tetracycline and topical therapy |
|