Patients
This trial represents a series of collected cases of patients treated for moderate to severe inflammatory facial acne. Enrolled patients were overall ineligible to standard dose of retinoids for health or personal reasons. A urine or blood pregnancy test was required for female subjects at the screening, baseline and then every 4 weeks for all the period of the study. Detailed criteria for inclusion and exclusion are listed in Table I.
Acne severity was graded according to the Investigator’s Global Assessment (IGA) scale (Table II) 66-68, by the treating physician. In total 12 cases were included, seven male and five female patients. Baseline grading ensured that 50% of the patients presented with moderate (IGA 3) and 50% with severe (IGA 4) acne (Table III).