This paper proposed the comparative study on Incoloy 825 Ni-based alloy and AISI 316L austenitic stainless steel dissimilar joints. Welding is accomplished by Nd: YAG pulsed laser beam welding process. This paper is about to investigate the process parameters like laser focal diameter, Power, and pulse frequency in LBW welding of above dissimilar plates. Characterization was conducted by optical microscopy, electron microscopy to understand the microstructural changes during welding. Micro-hardness and tensile tests are carried out to study the evolution of mechanical properties of solder joints. Based on the research work, laser beam welding has certain advantages over other welding techniques due to its less heat affected zone, high power intensity, high repetition rate. Among various analytical and experimental optimization methods, the Taguchi method is more efficient. So this experimentation is about to prove the weld efficiency of dissimilar metal can meet the requirements in oil and gas industries and other industries.