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Infectious Complications After Allogeneic Hematopoietic Stem Cell Transplantation in Children in a Bone Marrow Transplant Unit in Colombia
  • +4
  • Ana Bravo,
  • Jailer Arango,
  • Oscar Ramirez,
  • Carlos Portilla,
  • Pio López,
  • Juan Calle-Giraldo,
  • Eduardo Lopez-Medina
Ana Bravo
Universidad del Cauca
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Jailer Arango
Universidad del Valle
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Oscar Ramirez
Registro Poblacional de Cáncer de Cali
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Carlos Portilla
Escuela de Medicina, Universidad del Valle, Cali, Colombia
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Pio López
Centro de Estudios en Infectología Pediátrica
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Juan Calle-Giraldo
Universidad del Quindío
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Eduardo Lopez-Medina
Centro de Estudios en Infectología Pediátrica
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Abstract

To address the relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo-HSCT) in developing countries, we performed a retrospective cohort study of 139 children who underwent 150 allo-HSCTs in a hospital in Cali, Colombia. Most allo-HSCT (n=144, 96%) were followed by infections over the following year, primarily due to bacteria (4.3 per 1000 patient-days) and CMV (3.3 per 1000 patient-days). Most infections occurred in the first 30 days post HSTC. High mortality (n=44, 31.7%) was associated with infections, but has declined annually from 40% to 17% over the period covered (2012–2017).