Chromosomal Microarray Analysis
All cases showed chromosomal gains across the genome (Figure 3). The chromosomes with gains included 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 15, 16, 17, 18, 19, 20, 21, 22, and X. Additional findings included copy neutral loss of heterozygosity of whole chromosome 8 includingMYC at 8q24.3 and copy neutral loss of heterozygosity on chromosome 13. Pertinent negatives in this analysis included no relative gain of 1q, no apparent chromothripsis, no alterations of RELA orYAP1 , and no deletion of NF2 . A summary of patient chromosomal microarray analysis results can be seen in Table 2.