Study limitations:
We cannot compare Senning patients group with controls at peak
dobutamine stress, because control children had not indications for the
dobutamine stress test, with the high risk on them that was against the
ethical committee guidelines. This problem can be solved later on in
their adult life, as we will continue studying those patients and we
will compare them with adult controls who will be subjected to
Dobutamine stress echocardiography for any other reasons. A larger
series of patients and longer follow-up times are needed to establish
the safety of various stressors in these populations.