Demographic and clinical characteristics:
In this study; group I Senning patients included 20 (62.52 %) boys and
11 (35.48 %) girls, with a mean age of 12.88 ± 3.12 years, and mean
weight of 31.71 ± 9.17 Kg, while, group II controls included 15 (50.00
%) boys and 15 (50.00 %) girls, with a mean age of 12.50 ± 2.92 years,
and mean weight of 33.18 ± 8.96 Kg. In the Senning patient group, the
mean patients’ age at Senning operation was 11.2 ± 1.30 months, and 9
(29.03 %) patients had associated ventricular septal defect (VSD) and
were therefore referred to as ‘complex TGA; in these patients, the VSDs
were closed at the time of the atrial redirection surgeries, without
residual leaks. From the 31 Senning group; 9 (29.03 %) patients
presented with dyspnea grade II-IV, 3 (9.68 %) patients presented with
chest infection, and no patients exhibited arrhythmias.
As regard to hemodynamic data; oxygen saturation was significantly lower
in Senning patients than controls (97.75 ± 0.50 % vs. 99.15 ± 0.76 %
for group I and group II respectively, P = 0.04*), and heart rate was
significantly higher in Senning patients than controls (98.45 ± 15.76
bpm vs. 89.31 ±10.17 bpm for the group I and group II respectively, P =
0.01*). However, there was no significant difference between Senning
group and control group in blood pressure measurements (105.85 ± 13.31 /
71.75 ± 11.41 mmHg vs. 107.50 ± 14.55 / 72.00 ± 10.24 mmHg for the group
I and group II respectively, P = 0. 26).
Pro-BNP was significantly higher in Senning patients than controls
(531.54 ± 45.33 ng/L vs 115 ± 13.62 ng/L respectively, P <
0.001*).