Study limitations:
We cannot compare Senning patients group with controls at peak dobutamine stress, because control children had not indications for the dobutamine stress test, with the high risk on them that was against the ethical committee guidelines. This problem can be solved later on in their adult life, as we will continue studying those patients and we will compare them with adult controls who will be subjected to Dobutamine stress echocardiography for any other reasons. A larger series of patients and longer follow-up times are needed to establish the safety of various stressors in these populations.