Introduction:
Coronary artery disease (CAD) is one of the major concerns with
multifocal risk factors, including genetic and lifestyle-related
[1]. Coronary artery bypass grafting is still a therapy of choice
for complex ischemic heart disease and yields satisfactory long-term
outcomes [2].
One of the key cardiovascular pathogenetic processes is the loss of the
endothelium’s protective role [3]. Its’ pro-atherosclerotic
phenotype is characterized by a reduced nitric oxide production
compounded with vasoconstricting overactivity [4]. It has been
postulated that vascular endothelial dysfunction secondary to reduced
nitric oxide production, oxidative stress, and chronic inflammation is
linked with obesity [5]. The relationship between severity of
obesity and reduction of endothelial function affecting coronary
arteries has already been proved [6.7]. Impaired vasodilatory
capacity of coronary circulation precedes structural alterations and
carries significant prognostic information [8].
Recently, many authors underlined the impact of mutual correlation
between blood cellular components, such as platelet-to-lymphocyte (PLR)
or neutrophil-to-lymphocyte (NLR) ratios, and the outcomes of both
cardiac and non-cardiac medical interventions [9-11].
In this study, the predominant purpose was to estimate blood flow
through aorto-coronary bypass grafts implanted on the beating heart in
obese and non-obese patients and to determine its association with the
results of the patients’ preoperative blood morphology [12].