Objective: Patients with coronary artery bypass grafting require special care at home, and not being aware of this care before surgery can cause anxiety. This study aimed to determine the effect of home care training on anxiety and vital signs levels in CABG patients. Methods: This clinical trial study was performed on 80 patients undergoing CABG surgery in Farshchian Hospital in Hamadan, Iran, in January 2020. Samples were selected by convenience sampling and were randomly divided into intervention and control groups. The control group received only routine training, but the intervention group also received two-session training of home care. Data were collected using the Spielberger situational anxiety questionnaire and the vital signs checklist, then analyzed using descriptive and inferential statistics in SPSS software version 16. Results: The results showed that before the intervention, the mean scores of anxiety, heart rate, respiratory rate, temperature, systolic blood pressure, and diastolic blood pressure of the two groups were not significantly different(P>0/05). However, after the intervention, the mean score of anxiety, the heart rate, respiratory rate, systolic blood pressure, and diastolic blood pressure of the intervention group was lower than the control group significantly(P<0/05), But the mean temperature of the two groups showed no significant difference(P>0/05). Conclusions: Home care training before surgery reduces anxiety and vital signs, therefore the use of home care training before surgery is recommended in this group of patients.