4. Dose and Safety . An application of the repurposed drug within the approved dose ranges for its initial indications for which the pharmacokinetics and toxicology are documented as part of the registration for the drug’s initial indication. In particular to identify what is known about RAS inhibitors in regard to (a) observational data based upon administrative records, (b) the relationship between the existing Cmax and EC50 for new indication, (c) the historical safety of the proposed repurposed drug including knowledge of clinical maximal dose.