Figure 4: RBD (ACE2 contact residue) of closely relatedbetacoronaviruses
Alignment of SARS-CoV-2 against the most closely related viruses. Key
residues in the RBD of S1 subunit that make contact to the ACE2 receptor
are marked with blue boxes in both SARS-CoV-2 and related viruses. 6 key
AA residues involved in interaction with ACE2 receptor are 99% similar
between Guangdong-1/PS2 (Pangolin) and SARS-CoV-2. But only 1 key AA
residue is similar between Yunnan-RaTG13 (Bat) or SARS-CoV and
SARS-CoV-2. The figure is modified and adapted from Andersen et
al.