Figure 1: Structure of SARS-CoV-2
Schematic representation of the genome organization and functional
domains of SARS-CoV-2. The single-stranded RNA genomes of SARS-CoV and
SARS-CoV-2 encode two large genes, the ORF1a and ORF1b genes. ORF1a/b
(2/3 of the SARS-CoV-2 genome) in the 5′-terminal encodes polyproteins,
which form the viral replicase-transcriptase complex. The other ORFs
encode four main structural proteins: spike protein (S), envelope
protein (E), nucleocapsid protein (N) and membrane protein (M), as well
as accessory proteins.