Introduction

Spontaneous abortion occurs in 15%~25% of clinical pregnancy, among which about 5% women suffer from recurrent pregnancy loss[1,2]. Patients who have previous pregnancy loss experience tend to be more nervous and anxious, and are likely to take examination more frequently. In early pregnancy inspection, doctors hope to find cost-effective indicators to evaluate the pregnancy conditions and predict pregnancy outcomes, so as to timely adjust the treatment strategy and accurately make the decision to provide active treatment or not. Serum β-human chorionic gonadotropin (β-HCG) and progesterone (P) have been widely used in early pregnancy assessment, but the clinical significance and value of progesterone test are still controversial. Another reproductive hormone estradiol (E2) is also very important in pregnancy maintenance, but has not been used as widely as β-HCG and P. In this study, serum E2 and β-HCG levels were analyzed in early pregnancy women, to explore the clinical significance of dynamically monitoring E2 and β-HCG in assessing pregnancy conditions and predicting pregnancy outcomes.